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POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa [ Homo sapiens (human) ]

Gene ID: 5441, updated on 11-Oct-2014
Official Symbol
POLR2Lprovided by HGNC
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDaprovided by HGNC
Primary source
HGNC:HGNC:9199
See related
Ensembl:ENSG00000177700; HPRD:01155; MIM:601189; Vega:OTTHUMG00000133316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; RPB10beta
Summary
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
See POLR2L in Epigenomics, MapViewer
Location:
11p15
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (839721..842529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (839721..842529, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene calcium release activated channel regulator 2B Neighboring gene CD151 molecule (Raph blood group) Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) II (DNA directed) polypeptide L (POLR2L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
DNA repair TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
nucleotide-excision repair TAS
Traceable Author Statement
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase I promoter TAS
Traceable Author Statement
more info
PubMed 
termination of RNA polymerase III transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase I promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA-directed RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Names
DNA-directed RNA polymerases I, II, and III subunit RPABC5
RPB10 homolog
RNA polymerase II 7.6 kDa subunit
DNA-directed RNA polymerase III subunit L
RNA polymerases I, II, and III subunit ABC5
NP_066951.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021128.4NP_066951.1  DNA-directed RNA polymerases I, II, and III subunit RPABC5

    See proteins identical to NP_066951.1

    Status: REVIEWED

    Source sequence(s)
    BC005903, BC018649, BQ435190, BU679804
    Consensus CDS
    CCDS7720.1
    UniProtKB/Swiss-Prot
    P62875
    Related
    ENSP00000324124, OTTHUMP00000164439, ENST00000322028, OTTHUMT00000257114
    Conserved Domains (1) summary
    PLN00032
    Location:167
    PLN00032; DNA-directed RNA polymerase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    839721..842529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    655066..657876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    838762..841571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)