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TERF2IP TERF2 interacting protein [ Homo sapiens (human) ]

Gene ID: 54386, updated on 26-May-2016
Official Symbol
TERF2IPprovided by HGNC
Official Full Name
TERF2 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:19246
See related
Ensembl:ENSG00000166848 HPRD:05452; MIM:605061; Vega:OTTHUMG00000177136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAP1; DRIP5
Summary
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]
Orthologs
Location:
16q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (75647704..75657442)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75681602..75691340)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, tRNA specific 1 Neighboring gene lysyl-tRNA synthetase Neighboring gene double homeobox B Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 pseudogene 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystemReactive oxygen species (ROS), whose concentration increases in senescent cells due to oncogenic RAS-induced mitochondrial dysfunction (Moiseeva et al. 2009) or due to environmental stress, cause DNA...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic synapsis, organism-specific biosystem (from REACTOME)
    Meiotic synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...
  • Packaging Of Telomere Ends, organism-specific biosystem (from REACTOME)
    Packaging Of Telomere Ends, organism-specific biosystemMultiple steps, including C-strand resection, telomerase-mediated elongation, and C-strand synthesis are involved in processing and maintaining the telomere. Though this module posits a linear trans...
  • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Telomerase, organism-specific biosystem
    Regulation of Telomerase
  • Shelterin complex, organism-specific biosystem (from KEGG)
    Shelterin complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
  • Shelterin complex, conserved biosystem (from KEGG)
    Shelterin complex, conserved biosystemStructural complex; Genetic information processing; Replication system
  • Telomere Maintenance, organism-specific biosystem (from REACTOME)
    Telomere Maintenance, organism-specific biosystemTelomeres are protein-DNA complexes at the ends of linear chromosomes that are important for genome stability. Telomeric DNA in humans, as in many eukaryotic organisms, consists of tandem repeats (B...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT telomeric DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of DNA recombination at telomere ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of telomere maintenance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protection from non-homologous end joining at telomere ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
telomere capping TAS
Traceable Author Statement
more info
 
telomere maintenance IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase TAS
Traceable Author Statement
more info
PubMed 
telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Mre11 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromosome TAS
Traceable Author Statement
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear telomere cap complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
telosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
telomeric repeat-binding factor 2-interacting protein 1
Names
RAP1 homolog
TERF2-interacting telomeric protein 1
TRF2-interacting telomeric RAP1 protein
TRF2-interacting telomeric protein 1
dopamine receptor interacting protein 5
dopamine receptor-interacting protein 5
hRap1
repressor/activator protein 1 homolog
telomeric repeat binding factor 2, interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018975.3NP_061848.2  telomeric repeat-binding factor 2-interacting protein 1

    See identical proteins and their annotated locations for NP_061848.2

    Status: REVIEWED

    Source sequence(s)
    AA769291, AK307901, BC022428
    Consensus CDS
    CCDS32491.1
    UniProtKB/Swiss-Prot
    Q9NYB0
    Related
    ENSP00000300086, OTTHUMP00000255936, ENST00000300086, OTTHUMT00000435519
    Conserved Domains (2) summary
    cd11653
    Location:306399
    rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
    cd11655
    Location:133189
    rap1_myb-like; DNA-binding modules of yeast Rap1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    75647704..75657442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_933334.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    77094035..77103738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)