Display Settings:

Format

Send to:

Choose Destination

POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa [ Homo sapiens (human) ]

Gene ID: 5434, updated on 7-Dec-2014
Official Symbol
POLR2Eprovided by HGNC
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide E, 25kDaprovided by HGNC
Primary source
HGNC:HGNC:9192
See related
Ensembl:ENSG00000099817; HPRD:15946; MIM:180664; Vega:OTTHUMG00000181873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPB5; XAP4; RPABC1; hRPB25; hsRPB5
Summary
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq, Jul 2008]
See POLR2E in Epigenomics, MapViewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (1086579..1095392, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1086578..1095391, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 7 Neighboring gene histocompatibility (minor) HA-1 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch homolog 2 (Drosophila) Neighboring gene uncharacterized LOC102723798

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
DNA repair TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
nucleotide-excision repair TAS
Traceable Author Statement
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
termination of RNA polymerase III transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase I promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA-directed RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Names
DNA-directed RNA polymerases I, II, and III subunit RPABC1
RPB5 homolog
DNA-directed RNA polymerase II subunit E
DNA-directed RNA polymerase subunit RPABC1
RNA polymerases I, II, and III subunit ABC1
DNA directed RNA polymerase II 23 kda polypeptide
DNA-directed RNA polymerase II 23 kDa polypeptide
NP_002686.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002695.3NP_002686.2  DNA-directed RNA polymerases I, II, and III subunit RPABC1

    See proteins identical to NP_002686.2

    Status: REVIEWED

    Source sequence(s)
    AC004151, BC004441, DC414435
    Consensus CDS
    CCDS12056.1
    UniProtKB/Swiss-Prot
    P19388
    Related
    ENSP00000478303, OTTHUMP00000267716, ENST00000615234, OTTHUMT00000458044
    Conserved Domains (3) summary
    PLN03111
    Location:1209
    PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional
    pfam01191
    Location:137209
    RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
    pfam03871
    Location:195
    RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    1086579..1095392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259579.2XP_005259636.1  

    See proteins identical to XP_005259636.1

    UniProtKB/TrEMBL
    B4DJ89
    Conserved Domains (1) summary
    pfam01191
    Location:44116
    RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    1086181..1094986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    860059..868869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)