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Ezr ezrin [ Rattus norvegicus (Norway rat) ]

Gene ID: 54319, updated on 8-May-2016
Official Symbol
Ezrprovided by RGD
Official Full Name
ezrinprovided by RGD
Primary source
RGD:621161
See related
Ensembl:ENSRNOG00000018524
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Vil2
Summary
connects the microvillar cytoskeleton to the plasma membrane [RGD, Feb 2006]
Orthologs
Location:
1q11
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47287872..47331412, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (48590971..48634511, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 1 Neighboring gene synaptotagmin-like 3 Neighboring gene radial spoke 3 homolog Neighboring gene T-cell activation RhoGTPase activating protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC94076

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
S100 protein binding IEA
Inferred from Electronic Annotation
more info
 
S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
astral microtubule organization IEA
Inferred from Electronic Annotation
more info
 
astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
cellular protein complex localization IEA
Inferred from Electronic Annotation
more info
 
cellular protein complex localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cortical microtubule organization IEA
Inferred from Electronic Annotation
more info
 
cortical microtubule organization ISO
Inferred from Sequence Orthology
more info
 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
establishment of centrosome localization IEA
Inferred from Electronic Annotation
more info
 
establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
NOT establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
establishment or maintenance of apical/basal cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of apical/basal cell polarity ISO
Inferred from Sequence Orthology
more info
 
filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
NOT gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
intestinal D-glucose absorption IEA
Inferred from Electronic Annotation
more info
 
intestinal D-glucose absorption ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane to membrane docking IEA
Inferred from Electronic Annotation
more info
 
membrane to membrane docking ISO
Inferred from Sequence Orthology
more info
 
microvillus assembly IEA
Inferred from Electronic Annotation
more info
 
microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
NOT microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-2 secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-2 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
receptor internalization IEA
Inferred from Electronic Annotation
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
regulation of microvillus length IEA
Inferred from Electronic Annotation
more info
 
regulation of microvillus length ISO
Inferred from Sequence Orthology
more info
 
regulation of organelle assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of organelle assembly ISO
Inferred from Sequence Orthology
more info
 
sphingosine-1-phosphate signaling pathway IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate signaling pathway ISO
Inferred from Sequence Orthology
more info
 
terminal web assembly IEA
Inferred from Electronic Annotation
more info
 
terminal web assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Schwann cell microvillus IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
TCR signalosome IEA
Inferred from Electronic Annotation
more info
 
NOT colocalizes_with TCR signalosome ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
brush border ISO
Inferred from Sequence Orthology
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cell tip IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
filopodium ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with immunological synapse ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microspike IDA
Inferred from Direct Assay
more info
PubMed 
microvillus ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
uropod IEA
Inferred from Electronic Annotation
more info
 
uropod ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ezrin
Names
cytovillin
p81
villin 2
villin-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019357.1NP_062230.1  ezrin

    See identical proteins and their annotated locations for NP_062230.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081958
    UniProtKB/Swiss-Prot
    P31977
    Related
    ENSRNOP00000046593, ENSRNOT00000046746
    Conserved Domains (6) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    pfam00769
    Location:338586
    ERM; Ezrin/radixin/moesin family
    pfam09379
    Location:986
    FERM_N; FERM N-terminal domain
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    cd14473
    Location:98198
    FERM_B-lobe; FERM domain B-lobe
    cl22438
    Location:313375
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    47287872..47331412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    42655531..42699079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)