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Eif2s1 eukaryotic translation initiation factor 2 subunit 1 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 54318, updated on 8-May-2016
Official Symbol
Eif2s1provided by RGD
Official Full Name
eukaryotic translation initiation factor 2 subunit 1 alphaprovided by RGD
Primary source
RGD:620963
See related
Ensembl:ENSRNOG00000009432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
subunit of translational initiation factor eIF-2; forms ternary complex with methionyl-tRNAi and GTP and promotes the binding of the initiator tRNA to 40 S ribosomal subunits [RGD, Feb 2006]
Orthologs
Location:
6q24
Exon count:
8
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102048372..102073041)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (111422397..111447066)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene membrane palmitoylated protein 5 Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene uncharacterized LOC102547797

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC93488

Gene Ontology Provided by RGD

Function Evidence Code Pubs
poly(A) RNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ribosome binding ISO
Inferred from Sequence Orthology
more info
 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
mitophagy in response to mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translational initiation in response to stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 
positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of translational initiation in response to stress ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to manganese-induced endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
translation ISO
Inferred from Sequence Orthology
more info
 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
xenophagy IEA
Inferred from Electronic Annotation
more info
 
xenophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
eukaryotic translation initiation factor 2 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
glial limiting end-foot IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
translation initiation ternary complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 2 subunit 1
Names
EIF-2A
EIF-2alpha
eIF-2-alpha
eukaryotic translation initiation factor 2 subunit alpha
eukaryotic translation initiation factor 2, subunit 1 alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019356.1NP_062229.1  eukaryotic translation initiation factor 2 subunit 1

    See identical proteins and their annotated locations for NP_062229.1

    Status: PROVISIONAL

    Source sequence(s)
    J02646
    UniProtKB/Swiss-Prot
    P68101
    Related
    ENSRNOP00000013375, ENSRNOT00000013375
    Conserved Domains (3) summary
    cd04452
    Location:1489
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    PTZ00248
    Location:4315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
    pfam07541
    Location:130244
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    102048372..102073041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    96060793..96085462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)