Sstr2 somatostatin receptor 2 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Sstr2provided by RGD
Official Full Name: somatostatin receptor 2provided by RGD
Primary source: RGD:3763
See related: Ensembl:ENSRNOG00000002793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Smstr2
Summary: binds somatostatin; mediates signaling in response to thermal pain; may play a role in regulation of intestinal peristalsis [RGD, Feb 2006]

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Genomic context

Location :: 10q32.1

Sequence :: Chromosome: 10; NC_005109.2 (103246880..103254444)

See Sstr2 in MapViewer

Chromosome 10 - NC_005109.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protein phosphatase 1beta (PP1beta) is identified as a phosphatase for the cluster of phosphorylated threonines ((353)TTETQRT(359)) within the sst(2A) somatostatin receptor carboxyl terminus that mediates beta-arrestin binding using siRNA knock-down sc...
Title: Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Decreased level of somatostatin receptor type 2 mRNA and protein in diabetic rat atria leads to the dicrease of atrial natriuretic peptide (ANP) secretion due to an attenuation of suppressive effect of somatostatin on ANP secretion.
Title: Suppression of ANP secretion by somatostatin through somatostatin receptor type 2.
Selective activation of Sstr2 induces a feeding response in the light phase not associated with changes in gastric emptying.
Title: Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats.
The somatostatin analogs SOM230 and KE108 exhibit functional selectivity at SSTR2, behaving as agonists for some signaling pathways and antagonists for others. Thus they do not mimic the effects of the native peptide at this receptor target.
Title: Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways.
Somatostatin sst2A receptor participates in the development and maturation of specific neuronal populations during rat and human brain ontogenesis.
Title: The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth.
neither the glucagon-like peptide-1-induced stimulation of glucagon release nor its inhibition by 20 mmol/l glucose was altered by somatostatin antibody or SSTR2 antagonist administration
Title: Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas.
The inhibition of insulin secretion by somatostatin and somatostatin receptor 2 was attenuated by SNX-482. Taken together, somatostatin and somatostatin receptor 2 regulate [Ca(2+)](i) and insulin secretion in INS-1 cells via R-type channels.
Title: Characterization of voltage operated R-type Ca2+ channels in modulating somatostatin receptor subtype 2- and 3-dependent inhibition of insulin secretion from INS-1 cells.
These studies are the first to show stress-induced changes in amygdala sst2 expression and may represent one mechanism by which psychological stress is linked to adaptive and maladaptive behavioral responses.
Title: Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression.
the subpopulation of bulbospinal rostral ventrolateral medulla neurons that expresses the sst2A receptor sets sympathetic vasomotor output
Title: Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure.
The combined activation of SSTR1 and -2 shows a partial synergism as far as antiproliferative activity, whereas SSTR2 and -5 activation results in a response resembling the SSTR5 effects.
Title: Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2.

Submit: New GeneRIF Correction See all (31)

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:248525	BioGRID:108085	DLG3	BioGRID	PubMed	Two-hybrid
BioGRID:248525	BioGRID:116598	SHANK2	BioGRID	PubMed	Far Western; Two-hybrid
BioGRID:248525	BioGRID:112523	SNTA1	BioGRID	PubMed	Two-hybrid
BioGRID:248525	BioGRID:251104	Shank2	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
PDZ domain binding	ISO Inferred from Sequence Orthology more info
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
somatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed
somatostatin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
forebrain development	IEP Inferred from Expression Pattern more info	PubMed
inhibition of adenylate cyclase activity by G-protein signaling pathway	IEA Inferred from Electronic Annotation more info
inhibition of adenylate cyclase activity by G-protein signaling pathway	ISO Inferred from Sequence Orthology more info
neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
response to starvation	IEP Inferred from Expression Pattern more info	PubMed
spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
synaptic transmission	IEA Inferred from Electronic Annotation more info
synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info
membrane fraction	ISO Inferred from Sequence Orthology more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: somatostatin receptor type 2

Names: somatostatin receptor type 2; SS2R; SS2-R; SRIF-1; SS-2-R; somatostatin receptor subtype 2; somatotropin release-inhibiting factor receptor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019348.1 → NP_062221.1 somatostatin receptor type 2

Status: PROVISIONAL

Source sequence(s)

M96817

UniProtKB/Swiss-Prot

P30680

Related

ENSRNOP00000003735, ENSRNOT00000003735

Conserved Domains (2) summary

pfam00001
Location:66 – 312
Blast Score: 544

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:54 – 327
Blast Score: 134

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005109.2 Reference assembly (based on RGSC_v3.4)

Range

103246880..103254444

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000078.1 Alternate assembly (Rn_Celera)

Range

97271562..97278691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473948.1	EDM06514.1
		EDM06515.1
mRNA	M93273.1	AAA42165.1	OFA
mRNA	M96817.1	AAA42166.1
mRNA	X98234.1	CAA66886.1	Sprague-Dawley