Tpsab1 tryptase alpha/beta 1 [Rattus norvegicus] - Gene

Help top of page

Summary

Official Symbol: Tpsab1provided by RGD
Official Full Name: tryptase alpha/beta 1provided by RGD
Primary source: RGD:3066
See related: Ensembl:ENSRNOG00000024181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Mcpt7; TPSB1; rMCP-7
Summary: serine protease in mast cells [RGD, Feb 2006]

Help top of page

Genomic context

Location :: 10q12

Sequence :: Chromosome: 10; NC_005109.2 (14591590..14594005, complement)

See Tpsab1 in MapViewer

Chromosome 10 - NC_005109.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tryptase can stimulate myoblast proliferation and this effect is part of a signaling cascade dependent on PAR-2 activation and on the downstream activation of COX-2.
Title: Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2.

Submit: New GeneRIF Correction

Help top of page

Function	Evidence Code	Pubs
peptidase activity	IEA Inferred from Electronic Annotation more info
serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tryptase

Names: tryptase; MMCP-7; tryptase, skin; tryptase beta 1; mast cell protease 7; tryptase alpha/beta-1

NP_062195.2

EC 3.4.21.59

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019322.2 → NP_062195.2 tryptase precursor

Status: VALIDATED

Source sequence(s)

BC061983, U67910

UniProtKB/TrEMBL

G3V8E5

UniProtKB/Swiss-Prot

P27435

UniProtKB/TrEMBL

Q6P6W8

Related

ENSRNOP00000025095, ENSRNOT00000024767

Conserved Domains (1) summary

cd00190
Location:66 – 302
Blast Score: 667

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...