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Fgf2 fibroblast growth factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54250, updated on 17-May-2016
Official Symbol
Fgf2provided by RGD
Official Full Name
fibroblast growth factor 2provided by RGD
Primary source
RGD:2609
See related
Ensembl:ENSRNOG00000017392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
bFGF; Fgf-2
Summary
activates the MAP kinase signaling pathway; plays a role in synaptic transmission; induces cell proliferation [RGD, Feb 2006]
Orthologs
Location:
2q25
Exon count:
3
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (124081072..124134133)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (143689407..143742070)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene centrin 4 Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene nudix hydrolase 6 Neighboring gene spermatogenesis associated 5 Neighboring gene 60S ribosomal protein L29-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in coronary vascular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
chondroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
corticotropin hormone secreting cell differentiation IEA
Inferred from Electronic Annotation
more info
 
corticotropin hormone secreting cell differentiation ISO
Inferred from Sequence Orthology
more info
 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
growth factor dependent regulation of skeletal muscle satellite cell proliferation IEA
Inferred from Electronic Annotation
more info
 
growth factor dependent regulation of skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
organ induction ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell fate specification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
regulation of retinal cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
regulation of retinal cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to axon injury ISO
Inferred from Sequence Orthology
more info
 
stem cell development IEA
Inferred from Electronic Annotation
more info
 
stem cell development ISO
Inferred from Sequence Orthology
more info
 
substantia nigra development IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development ISO
Inferred from Sequence Orthology
more info
 
thyroid-stimulating hormone-secreting cell differentiation IEA
Inferred from Electronic Annotation
more info
 
thyroid-stimulating hormone-secreting cell differentiation ISO
Inferred from Sequence Orthology
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
fibroblast growth factor 2
Names
HBGF-2
basic fibroblast growth factor
heparin-binding growth factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019305.2NP_062178.1  fibroblast growth factor 2 precursor

    See identical proteins and their annotated locations for NP_062178.1

    Status: VALIDATED

    Source sequence(s)
    AABR07010110, M22427
    UniProtKB/Swiss-Prot
    P13109
    Related
    ENSRNOP00000023388, ENSRNOT00000023388
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    124081072..124134133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    115183003..115237310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)