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KCNK10 potassium two pore domain channel subfamily K member 10 [ Homo sapiens (human) ]

Gene ID: 54207, updated on 8-May-2016
Official Symbol
KCNK10provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 10provided by HGNC
Primary source
HGNC:HGNC:6273
See related
Ensembl:ENSG00000100433 HPRD:12061; MIM:605873; Vega:OTTHUMG00000170743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREK2; TREK-2; K2p10.1; PPP1R97
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Orthologs
Location:
14q31.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (88180108..88326912, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88646452..88793256, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928791 Neighboring gene long intergenic non-protein coding RNA 1146 Neighboring gene uncharacterized LOC105370613 Neighboring gene uncharacterized LOC105370612 Neighboring gene spermatogenesis associated 7 Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase, non-receptor type 21

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
NHGRI GWA Catalog
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
    Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • TWIK related potassium channel (TREK), organism-specific biosystem (from REACTOME)
    TWIK related potassium channel (TREK), organism-specific biosystemTREK1 and TREK 2 are activated by physiochemical changes like stretch, convex deformation of the plasma membrane, depolarization, heat and intracellular acidosis. Polyunsaturated fatty acids (PUFA) i...
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ43399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
memory IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
potassium channel subfamily K member 10
Names
2P domain potassium channel TREK2
TREK-2 K(+) channel subunit
TWIK-related K+ channel 2
outward rectifying potassium channel protein TREK-2
potassium channel TREK-2
potassium channel, subfamily K, member 10
potassium channel, two pore domain subfamily K, member 10
protein phosphatase 1, regulatory subunit 97

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021161.4NP_066984.1  potassium channel subfamily K member 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_066984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TREK2 splice variant a) encodes the shortest isoform (1).
    Source sequence(s)
    AF279890, AI693366, AL049834, AL133279, U79244
    Consensus CDS
    CCDS9880.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000343104, OTTHUMP00000244287, ENST00000340700, OTTHUMT00000410167
    Conserved Domains (1) summary
    pfam07885
    Location:144203
    Ion_trans_2; Ion channel
  2. NM_138317.2NP_612190.1  potassium channel subfamily K member 10 isoform 2

    See identical proteins and their annotated locations for NP_612190.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TREK2 splice variant c) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF279890, AI693366, AK313499, AL133279, EU978939, U79244
    Consensus CDS
    CCDS9881.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000312811, OTTHUMP00000244289, ENST00000319231, OTTHUMT00000410169
    Conserved Domains (1) summary
    pfam07885
    Location:149208
    Ion_trans_2; Ion channel
  3. NM_138318.2NP_612191.1  potassium channel subfamily K member 10 isoform 3

    See identical proteins and their annotated locations for NP_612191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as TREK2 splice variant b) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF279890, AF385399, AI693366, AL133279, BC075021, EU978940, U79244
    Consensus CDS
    CCDS9882.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000310568, OTTHUMP00000244288, ENST00000312350, OTTHUMT00000410168
    Conserved Domains (1) summary
    pfam07885
    Location:149208
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    88180108..88326912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536840.1XP_011535142.1  

    Conserved Domains (1) summary
    pfam07885
    Location:1675
    Ion_trans_2; Ion channel

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    88584550..88731289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)