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    DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 54165, updated on 5-Feb-2012
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    Summary

    Official Symbol
    DCUN1D1provided by HGNC
    Official Full Name
    DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:18184
    See related
    Ensembl:ENSG00000043093; HPRD:12067; MIM:605905; Vega:OTTHUMG00000158314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
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    Genomic context

    Location :
    3q26.3
    Sequence :
    Chromosome: 3; NC_000003.11 (182660559..182698326, complement)
    See DCUN1D1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7-like 1 pseudogene 8 Neighboring gene ATPase, class VI, type 11B Neighboring gene eukaryotic translation initiation factor 3, subunit E pseudogene 4 Neighboring gene chromosome 9 open reading frame 85 pseudogene Neighboring gene methylcrotonoyl-CoA carboxylase 1 (alpha) Neighboring gene lysosomal-associated membrane protein 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1. Wu K, et al. J Biol Chem, 2011 Sep 30. PMID 21813641.
    3. DCUN1D1 is a risk factor for frontotemporal lobar degeneration. Villa C, et al. Eur J Neurol, 2009 Jul. PMID 19473369.
    4. SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2. O-charoenrat P, et al. Clin Cancer Res, 2008 Nov 1. PMID 18980971.
    5. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim AY, et al. J Biol Chem, 2008 Nov 28. PMID 18826954.

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
      Title: Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1.
    2. The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold.
      Title: DCUN1D1 is a risk factor for frontotemporal lobar degeneration.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: DCUN1D1 is a risk factor for frontotemporal lobar degeneration.
    4. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
      Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
    5. SCCRO-induced invasion involves activation of MMP2 transcription in an AP2- and p53-dependent manner.
      Title: SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
    6. SCCRO regulates Gli1--a key regulator of the hedgehog (HH) pathway.
      Title: Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas.
    7. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.
      Title: Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96GG9 Q15038 DAZAP2    HPRD  PubMed  
    Q96GG9 Q13571 LAPTM5    HPRD  PubMed  
    Q96GG9 Q9Y3C5 RNF11    HPRD  PubMed  
    Q96GG9 Q15796 SMAD2    HPRD  PubMed  
    Q96GG9 Q9HCM9 TRIM39    HPRD  PubMed  
    BioGRID:119920 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119920 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119920 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:119920 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119920 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119920 BioGRID:113743 CUL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119920 BioGRID:115143 DAZAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:119920 BioGRID:110811 NEDD4    BioGRID  PubMed Biochemical Activity 
    BioGRID:119920 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119920 BioGRID:121170 TRIM39    BioGRID  PubMed Two-hybrid 
    BioGRID:119920 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119920 BioGRID:114504 UBE2M    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    DCN1-like protein 1
    Names
    DCN1-like protein 1
    RP42 homolog
    DCUN1 domain-containing protein 1
    squamous cell carcinoma-related oncogene
    defective in cullin neddylation protein 1-like protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020640.2 → NP_065691.2  DCN1-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AK025764, CD687300
      Consensus CDS
      CCDS3240.1
      UniProtKB/Swiss-Prot
      Q96GG9
      Related
      ENSP00000292782, OTTHUMP00000212783, ENST00000292782, OTTHUMT00000350658
      Conserved Domains (1) summary
      pfam03556
      Location:134 – 248
      Blast Score: 460
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      182660559..182698326, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      180065325..180102962, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092953.7 (20909..58676) None
    genomic CH471052.2 EAW78341.1
      EAW78342.1
      EAW78343.1
    genomic CS104944.1 CAJ01275.1
    genomic CS185538.1 CAJ42719.1
    genomic HI999504.1 CCA61624.1
    mRNA AF292100.2 AAG00606.2
    mRNA AF456425.1 AAL78672.1
    mRNA AF456426.1 AAL78673.1
    mRNA AK025764.1 BAB15235.1
    mRNA AK056335.1 BAG51680.1
    mRNA AK126909.1 None
    mRNA AK297328.1 BAG59788.1
    mRNA AK314480.1 BAG37084.1
    mRNA BC009478.2 AAH09478.1
    mRNA BC013163.1 AAH13163.2
    mRNA CD687300.1 None
    other-genetic HQ448015.1 ADQ32496.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q96GG9.1 GenPept UniProtKB/Swiss-Prot:Q96GG9
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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      Supplemental Content

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      Links

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