en1b engrailed homeobox 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: en1bprovided by ZNC
Official Full Name: engrailed homeobox 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-6
See related: Ensembl:ENSDARG00000098730 AllianceGenome:ZFIN:ZDB-GENE-980526-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eng4; eng1b; wu:fc84e11; zgc:113499
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be active in nucleus. Is expressed in myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (7679225..7683374)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (6995891..6999941)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

marks a class of inhibitory interneurons that seems to provide all of the ipsilateral glycinergic inhibition in the spinal cord of embryonic and larval fish.
Title: Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron.

Submit: New GeneRIF Correction

General gene information

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Markers

fc84e11.x1 (e-PCR)
- UniSTS:188335

fd23c06.y1 (e-PCR)
- UniSTS:195306

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis involved in innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron fate commitment	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein engrailed-1; homeobox protein engrailed-1b

Names: engrailed 1b; engrailed 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013498.2 → NP_001013516.1 homeobox protein engrailed-1b

See identical proteins and their annotated locations for NP_001013516.1

Status: PROVISIONAL

Source sequence(s)

BC091669

UniProtKB/TrEMBL

B2GSI8, Q5BJ08

Related

ENSDARP00000150261.1, ENSDART00000190070.1

Conserved Domains (2) summary

pfam00046
Location:187 → 240

Homeobox; Homeobox domain

pfam10525
Location:242 → 271

Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

7679225..7683374

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305884.3 → XP_009304159.1 homeobox protein engrailed-1 isoform X1

UniProtKB/TrEMBL

A0A8M3B3Y5

Conserved Domains (2) summary

pfam00046
Location:191 → 244

Homeobox; Homeobox domain

pfam10525
Location:246 → 275

Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain