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PNLIPRP1 pancreatic lipase related protein 1 [ Homo sapiens (human) ]

Gene ID: 5407, updated on 26-May-2016
Official Symbol
PNLIPRP1provided by HGNC
Official Full Name
pancreatic lipase related protein 1provided by HGNC
Primary source
HGNC:HGNC:9156
See related
Ensembl:ENSG00000187021 HPRD:05109; MIM:604422; Vega:OTTHUMG00000019109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP1
Orthologs
Location:
10q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (116590415..116609175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118350478..118368687)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene chromosome 10 open reading frame 82 Neighboring gene uncharacterized LOC105378499

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog
  • Acylglycerol degradation, organism-specific biosystem (from KEGG)
    Acylglycerol degradation, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
  • Acylglycerol degradation, conserved biosystem (from KEGG)
    Acylglycerol degradation, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
  • Digestion of dietary lipid, organism-specific biosystem (from REACTOME)
    Digestion of dietary lipid, organism-specific biosystemDietary lipids such as long-chain triacylglycerols and cholesterol esters are digested in the stomach and small intestine to yield long-chain fatty acids, monoacylglycerols, glycerol and cholesterol ...
  • Fat digestion and absorption, organism-specific biosystem (from KEGG)
    Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Fat digestion and absorption, conserved biosystem (from KEGG)
    Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Glycerolipid metabolism, organism-specific biosystem (from KEGG)
    Glycerolipid metabolism, organism-specific biosystem
    Glycerolipid metabolism
  • Glycerolipid metabolism, conserved biosystem (from KEGG)
    Glycerolipid metabolism, conserved biosystem
    Glycerolipid metabolism
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
NOT extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
inactive pancreatic lipase-related protein 1
Names
pancreatic lipase-related protein 1
NP_001290064.1
NP_006220.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303135.1NP_001290064.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001290064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK130236, BC025784, BP323340, CD622211
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315
    Related
    ENSP00000433933, OTTHUMP00000230058, ENST00000528052, OTTHUMT00000384633
    Conserved Domains (3) summary
    TIGR03230
    Location:50456
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:52349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
  2. NM_006229.3NP_006220.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_006220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005233, BC025784, CD622211, M93283
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315
    Related
    ENSP00000351695, OTTHUMP00000020567, ENST00000358834, OTTHUMT00000050536
    Conserved Domains (3) summary
    TIGR03230
    Location:50456
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:52349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    116590415..116609175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539868.1XP_011538170.1  

    See identical proteins and their annotated locations for XP_011538170.1

    UniProtKB/Swiss-Prot
    P54315
    Conserved Domains (3) summary
    TIGR03230
    Location:50456
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:52349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
  2. XM_011539869.1XP_011538171.1  

    Conserved Domains (2) summary
    cd00707
    Location:1200
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:207318
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

RNA

  1. XR_945774.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    118633602..118651819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)