CSNK1G1 casein kinase 1, gamma 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CSNK1G1provided by HGNC
Official Full Name: casein kinase 1, gamma 1provided by HGNC
Primary source: HGNC:2454
See related: Ensembl:ENSG00000169118; MIM:606274; Vega:OTTHUMG00000133019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CK1gamma1
Summary: This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]

Help top of page

Genomic context

Location :: 15q22.1-q22.31

Sequence :: Chromosome: 15; NC_000015.9 (64457716..64648442, complement)

See CSNK1G1 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

casein kinase 1 gamma 1 phosphorylates claspin
Title: Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.
A 1756 bp cDNA encoded human protein kinase CK1 (438 AA, mol wt 50.272 Da, isoelectric point of 9.37) mapping to chromosome 15q22.
Title: Molecular cloning, mapping and characterization of a human CK1gamma1 gene.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q9HCP0	Q12778	FOXO1	HPRD	PubMed
Q9HCP0	Q96A00	PPP1R14A	HPRD	PubMed
BioGRID:119824	BioGRID:123217	C2orf44	BioGRID	PubMed	Two-hybrid
BioGRID:119824	BioGRID:128461	FAM219A	BioGRID	PubMed	Two-hybrid
BioGRID:119824	BioGRID:115604	IKZF1	BioGRID	PubMed	Two-hybrid
BioGRID:119824	BioGRID:117141	MKRN1	BioGRID	PubMed	Two-hybrid
BioGRID:119824	BioGRID:127550	RUNDC3B	BioGRID	PubMed	Two-hybrid
BioGRID:119824	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: casein kinase I isoform gamma-1

Names: casein kinase I isoform gamma-1; CKI-gamma 1

NP_071331.2

EC 2.7.11.1

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022048.3 → NP_071331.2 casein kinase I isoform gamma-1

Status: VALIDATED

Source sequence(s)

AC100840, AL832551, DB094870

Consensus CDS

CCDS10192.2

UniProtKB/Swiss-Prot

Q9HCP0

Related

ENSP00000305777, OTTHUMP00000163976, ENST00000303052, OTTHUMT00000256605

Conserved Domains (3) summary

COG0515
Location:43 – 394
Blast Score: 265

SPS1; Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]

pfam12605
Location:331 – 392
Blast Score: 205

CK1gamma_C; Casein kinase 1 gamma C terminal

cd00180
Location:50 – 244
Blast Score: 304

PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

64457716..64648442, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

41282388..41472528, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC087632.10 (74987..130888)	None
genomic	AC100840.2	None
genomic	AC110054.4	None
genomic	CH471082.1	EAW77670.1
		EAW77671.1
		EAW77673.1
		EAW77676.1
		EAW77677.1
		EAW77678.1
mRNA	AB042562.1	BAB17838.1
mRNA	AB042563.1	BAB17839.1
mRNA	AF223357.2	AAO12758.2
mRNA	AK023779.1	None
mRNA	AK025179.1	None
mRNA	AK026957.1	BAB15601.1
mRNA	AK126968.1	None
mRNA	AK225960.1	None
mRNA	AL832551.1	CAI46142.1
mRNA	BC017236.2	AAH17236.2
mRNA	BC062995.1	None
mRNA	BC077731.1	None
mRNA	BC130613.1	AAI30614.1
mRNA	BC136504.1	AAI36505.1
mRNA	CF593592.1	None
mRNA	DB094870.1	None
other-genetic	HQ258250.1	ADR83004.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q8IXA3	GenPept	UniProtKB/TrEMBL:Q8IXA3
Q9H5M4	GenPept	UniProtKB/TrEMBL:Q9H5M4
Q9HCP0.1	GenPept	UniProtKB/Swiss-Prot:Q9HCP0