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    PELO pelota homolog (Drosophila) [ Homo sapiens ]

    Gene ID: 53918, updated on 11-May-2012
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    Summary

    Official Symbol
    PELOprovided by HGNC
    Official Full Name
    pelota homolog (Drosophila)provided by HGNC
    Primary source
    HGNC:8829
    Locus tag
    CGI-17
    See related
    Ensembl:ENSG00000152684; HPRD:09309; MIM:605757; Vega:OTTHUMG00000096973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-17; PRO1770
    Summary
    This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q11.2
    Sequence :
    Chromosome: 5; NC_000005.9 (52083774..52098451)
    See PELO in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17 pseudogene 11 Neighboring gene KIAA1919 pseudogene Neighboring gene integrin, alpha 1 Neighboring gene ribosomal protein L17 pseudogene 21 Neighboring gene integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. Pisareva VP, et al. EMBO J, 2011 May 4. PMID 21448132.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1.
      Title: Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
      Title: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
    6. thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2.
      Title: Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:119818 BioGRID:111783 ABCD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:114579 AIFM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:120511 FANCI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:120433 HEATR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:110726 MYO1D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:119570 PTPLAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:114164 SLC25A12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:124961 TIMM50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119818 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PELO gene: The PELO gene is conserved in dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein pelota homolog
    Names
    protein pelota homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015946.4 → NP_057030.3  protein pelota homolog

      Status: REVIEWED

      Source sequence(s)
      AY117399
      Consensus CDS
      CCDS3956.1
      UniProtKB/Swiss-Prot
      Q9BRX2
      Related
      ENSP00000274311, OTTHUMP00000122446, ENST00000274311, OTTHUMT00000214040
      Conserved Domains (4) summary
      COG1537
      Location:1 – 371
      Blast Score: 777
      PelA; Predicted RNA-binding proteins [General function prediction only]
      pfam03465
      Location:271 – 370
      Blast Score: 358
      eRF1_3; eRF1 domain 3
      pfam03463
      Location:1 – 131
      Blast Score: 415
      eRF1_1; eRF1 domain 1
      pfam03464
      Location:136 – 268
      Blast Score: 375
      eRF1_2; eRF1 domain 2

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      52083774..52098451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      49055620..49070302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026230.5 (58173..72850) None
    genomic AF143952.2 AAG22575.1
    genomic CH471123.1 EAW54864.1
      EAW54870.1
    mRNA AF118075.1 AAF22019.1
    mRNA AF132951.1 AAD27726.1
    mRNA AF139828.1 AAG22574.1
    mRNA AK025729.1 None
    mRNA AK056144.1 BAG51633.1
    mRNA AK312633.1 None
    mRNA AY117399.1 AAM89414.1
    mRNA BC005889.2 AAH05889.1
    mRNA BC007249.2 AAH07249.1
    mRNA BC007650.1 AAH07650.1
    mRNA BC022789.1 AAH22789.1
    other-genetic DQ892950.2 ABM83876.1
    other-genetic DQ896198.2 ABM87197.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BRX2.2 GenPept UniProtKB/Swiss-Prot:Q9BRX2
    Q9UHT8 GenPept UniProtKB/TrEMBL:Q9UHT8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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