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PML promyelocytic leukemia [ Homo sapiens (human) ]

Gene ID: 5371, updated on 11-Sep-2014
Official Symbol
PMLprovided by HGNC
Official Full Name
promyelocytic leukemiaprovided by HGNC
Primary source
HGNC:HGNC:9113
See related
Ensembl:ENSG00000140464; HPRD:00023; MIM:102578; Vega:OTTHUMG00000137607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYL; RNF71; PP8675; TRIM19
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Location:
15q22
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (73994673..74047819)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74287014..74340160)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene LOXL1 antisense RNA 1 Neighboring gene lysyl oxidase-like 1 Neighboring gene stomatin (EPB72)-like 1 Neighboring gene DNM1 pseudogene 33 Neighboring gene golgin A6 family, member A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia PubMed
env Interactions between tumor suppressor protein PML, TopBP1 and ATM exhibit in HIV-1 Env-elicited syncytia PubMed
env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
Tat tat Data suggests that PML proteins regulate Tat-mediated transcriptional activation by modulating the availability of cyclin T1 and other essential cofactors to the transcription machinery PubMed
integrase gag-pol HIV-1 preintegration complexes containing HIV-1 integrase induce the cytoplasmic recruitment of integrase interactor 1 (INI1, hSNF5) and PML and associate with these cellular proteins before migrating to the nucleus PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
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  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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  • DNA damage response, organism-specific biosystem (from WikiPathways)
    DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    TGF-beta receptor signaling, organism-specific biosystem
    TGF-beta receptor signaling
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
SUMO binding IPI
Inferred from Physical Interaction
more info
PubMed 
cobalt ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
PML body organization IDA
Inferred from Direct Assay
more info
PubMed 
PML body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
cellular senescence IDA
Inferred from Direct Assay
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
common-partner SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process involved in mammary gland involution IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 
protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MHC class I biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 
response to UV IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
PML body TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein PML
Names
protein PML
RING finger protein 71
promyelocytic leukemia protein
tripartite motif protein TRIM19
probable transcription factor PML
promyelocytic leukemia, inducer of
tripartite motif-containing protein 19

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029036.1 

    Range
    5001..58147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002675.3NP_002666.1  protein PML isoform 6

    See proteins identical to NP_002666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (6, also known as PML-IV, PML-X and TRIM19zeta) contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BF510860, X63131
    Consensus CDS
    CCDS45297.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000378567, OTTHUMP00000249963, ENST00000395135, OTTHUMT00000421815
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 94
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 86
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240571
    Blast Score: 1349
    DUF3583; Protein of unknown function (DUF3583)
  2. NM_033238.2NP_150241.2  protein PML isoform 1

    See proteins identical to NP_150241.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as TRIM19alpha).
    Source sequence(s)
    AB209411, AC013486, M79462, X63131
    Consensus CDS
    CCDS10255.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000268058, OTTHUMP00000174946, ENST00000268058, OTTHUMT00000269021
    Conserved Domains (4) summary
    smart00336
    Location:124166
    Blast Score: 100
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 91
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240571
    Blast Score: 1377
    DUF3583; Protein of unknown function (DUF3583)
    cl10012
    Location:610758
    Blast Score: 105
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  3. NM_033239.2NP_150242.1  protein PML isoform 9

    See proteins identical to NP_150242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (9, also known as PML-II and TRIM19kappa) contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC034251, X63131
    Consensus CDS
    CCDS10257.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000268059, OTTHUMP00000174962, ENST00000268059, OTTHUMT00000269039
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 96
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 89
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240570
    Blast Score: 1336
    DUF3583; Protein of unknown function (DUF3583)
  4. NM_033240.2NP_150243.2  protein PML isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX647287, X63131
    Consensus CDS
    CCDS45298.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000395576, OTTHUMP00000249969, ENST00000435786, OTTHUMT00000421821
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 93
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 85
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240570
    Blast Score: 1329
    DUF3583; Protein of unknown function (DUF3583)
  5. NM_033244.3NP_150247.2  protein PML isoform 5

    See proteins identical to NP_150247.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (5, also known as PML-3B, PML-VI and TRIM19epsilon) contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF230405, BC034251, X63131
    Consensus CDS
    CCDS45299.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000394642, OTTHUMP00000249968, ENST00000436891, OTTHUMT00000421820
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 91
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 83
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240555
    Blast Score: 1270
    DUF3583; Protein of unknown function (DUF3583)
  6. NM_033246.2NP_150249.1  protein PML isoform 7

    See proteins identical to NP_150249.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (7, also known as PML-6B, PML-VIB, TRIM19eta and TRIM19iota) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BF510860, X63131
    Consensus CDS
    CCDS45300.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000353004, OTTHUMP00000249971, ENST00000359928, OTTHUMT00000421823
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 85
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240418
    Blast Score: 897
    DUF3583; Protein of unknown function (DUF3583)
  7. NM_033247.2NP_150250.2  protein PML isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (8, also known as PML-VII and TRIM19theta) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC034251, X63131
    Consensus CDS
    CCDS10256.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000378564, OTTHUMP00000174961, ENST00000395132, OTTHUMT00000269038
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 85
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240418
    Blast Score: 893
    DUF3583; Protein of unknown function (DUF3583)
  8. NM_033249.2NP_150252.1  protein PML isoform 10

    See proteins identical to NP_150252.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (10, also known as PML-4A, PML-IVA and TRIM19lambda) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BF510860, X63131
    Consensus CDS
    CCDS58386.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000457023, OTTHUMP00000249970, ENST00000564428, OTTHUMT00000421822
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 92
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 83
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240523
    Blast Score: 1404
    DUF3583; Protein of unknown function (DUF3583)
  9. NM_033250.2NP_150253.2  protein PML isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (11, also known as PML-2A and PML-IIA) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC034251, X63131
    Consensus CDS
    CCDS10258.1
    UniProtKB/Swiss-Prot
    P29590
    Related
    ENSP00000315434, OTTHUMP00000174963, ENST00000354026, OTTHUMT00000269040
    Conserved Domains (3) summary
    smart00336
    Location:124166
    Blast Score: 95
    BBOX; B-Box-type zinc finger
    cd00162
    Location:5795
    Blast Score: 87
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam12126
    Location:240522
    Blast Score: 1393
    DUF3583; Protein of unknown function (DUF3583)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    73994673..74047819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    51118849..51172183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    74404975..74458114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)