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    PML promyelocytic leukemia [ Homo sapiens (human) ]

    Gene ID: 5371, updated on 16-Jun-2013
    Official Symbol
    PMLprovided by HGNC
    Official Full Name
    promyelocytic leukemiaprovided by HGNC
    Primary source
    HGNC:9113
    See related
    Ensembl:ENSG00000140464; HPRD:00023; MIM:102578; Vega:OTTHUMG00000137607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYL; RNF71; PP8675; TRIM19
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Location :
    15q22
    Sequence :
    Chromosome: 15; NC_000015.9 (74287014..74340160)
    See PML in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene LOXL1 antisense RNA 1 Neighboring gene lysyl oxidase-like 1 Neighboring gene stomatin (EPB72)-like 1 Neighboring gene DNM1 pseudogene 33 Neighboring gene golgin A6 family, member A

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Analysis of SUMOylated proteins using SUMO-traps. Da Silva-Ferrada E, et al. Sci Rep, 2013. PMID 23604351.
    2. Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies: IMPLICATIONS FOR DEGRADATION OF NRF2 IN THE NUCLEUS. Malloy MT, et al. J Biol Chem, 2013 May 17. PMID 23543742.
    3. Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation. Erker Y, et al. Mol Cell Biol, 2013 Jun. PMID 23530056.
    4. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Iwanami A, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23440206.
    5. Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection. Glass M, et al. J Virol, 2013 Feb. PMID 23221561.

    See all (396) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PML is an essential regulator of TNFalpha signaling, and together they synergistically regulate cell adhesion by engaging multiple molecular mechanisms.
      Title: Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells.
    2. Postulate that detection of PML cytoplasmic particles in patient fibroblasts could become a valuable marker for diagnosis of disease development in laminopathies.
      Title: Cytoplasmic localization of PML particles in laminopathies.
    3. a unique role for PML in mTOR and EGFR inhibitor resistance and provide a strong rationale for a combination therapeutic strategy to overcome it.
      Title: PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.
    4. The PML mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in proliferative diabetic retinopathy patients than control patients.
      Title: Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy.
    5. Authors conclude that several ND10 components, including Daxx, the promyelocytic leukemia (PML) protein, and Sp100 cooperate in an additive manner to regulate herpes simplex virus type 1 and human cytomegalovirus infection.
      Title: Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection.
    6. Coimmunoprecipitation assays showed that adenoviral oncogene E1A-13S preferentially interacts with only one (PML-II) of at least six nuclear human PML isoforms.
      Title: The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription.
    7. PML is required for efficient IFN-gamma-induced MHC II gene transcription through regulation of the class II transactivator (CIITA)
      Title: PML promotes MHC class II gene expression by stabilizing the class II transactivator.
    8. results suggest that PML expression was positively associated with IL-6 expression in patients and was also related to tumor development and resistance to treatment in multiple myeloma.
      Title: Association of promyelocytic leukemia protein with expression of IL-6 and resistance to treatment in multiple myeloma.
    9. PML-RARA rearrangement is associated with good response to therapy in acute myeloid leukemia.
      Title: A novel hierarchical prognostic model of AML solely based on molecular mutations.
    10. analysis of a cryptic PML-RARA translocation in a patient with acute promyelocytic leukemia [case report]
      Title: Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation.
    Submit: New GeneRIF Correction See all (216)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia PubMed
    env Interactions between tumor suppressor protein PML, TopBP1 and ATM exhibit in HIV-1 Env-elicited syncytia PubMed
    env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
    Tat, p14 tat Data suggests that PML proteins regulate Tat-mediated transcriptional activation by modulating the availability of cyclin T1 and other essential cofactors to the transcription machinery PubMed
    pol gag-pol HIV-1 preintegration complexes containing HIV-1 integrase induce the cytoplasmic recruitment of integrase interactor 1 (INI1, hSNF5) and PML and associate with these cellular proteins before migrating to the nucleus PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    AAB19601.2 AURKA    BIND  PubMed PML3 interacts with Aurora A. 
    NP_002666.1 NP_001175.1 ATR    BIND  PubMed ATR phosphorylates PML. 
    NP_002666.1 NP_002383.1 MDM2    BIND  PubMed PML interacts with Mdm2. 
    NP_002666.1 NP_002458.1 MYC    BIND  PubMed Myc interacts with PML. This interaction was modelled on a demonstrated interaction between mouse Myc and human PML. 
    NP_002666.1 NP_000966.2 RPL11    BIND  PubMed PML interacts with L11 in the nucleolus. 
    NP_002666.1 NP_001003652.1 SMAD2    BIND  PubMed cPML interacts with Smad2. 
    NP_002666.1 NP_005893.1 SMAD3    BIND  PubMed cPML interacts with Smad3. 
    NP_002666.1 NP_004603.1 TGFBR1    BIND  PubMed cPML interacts with T-beta-RI. 
    NP_002666.1 NP_003233.3 TGFBR2    BIND  PubMed cPML interacts with T-beta-RII. 
    NP_002666.1 NP_004790.2 ZFYVE9    BIND  PubMed cPML interacts with SARA. 
    P29590 Q9GZV1 ANKRD2    HPRD  PubMed  
    P29590 Q99856 ARID3A    HPRD  PubMed  
    P29590 P27540 ARNT    HPRD  PubMed  
    P29590 O14965 AURKA    HPRD  PubMed  
    P29590 P10415 BCL2    HPRD  PubMed  
    P29590 O60563 CCNT1    HPRD  PubMed  
    P29590 Checkpoint protein with FHA and ring finger domains CHFR    HPRD  PubMed  
    P29590 Q92793 CREBBP    HPRD  PubMed  
    P29590 P68400 CSNK2A1    HPRD  PubMed  
    P29590 Q9UER7 DAXX    HPRD  PubMed  
    P29590 P06730 EIF4E    HPRD  PubMed  
    P29590 Q99607 ELF4    HPRD  PubMed  
    P29590 Q09472 EP300    HPRD  PubMed  
    P29590 P23769 GATA2    HPRD  PubMed  
    P29590 Q13547 HDAC1    HPRD  PubMed  
    P29590 Q92769 HDAC2    HPRD  PubMed  
    P29590 O15379 HDAC3    HPRD  PubMed  
    P29590 Q03014 HHEX    HPRD  PubMed  
    P29590 Q16539 MAPK14    HPRD  PubMed  
    P29590 Q00987 MDM2    HPRD  PubMed  
    P29590 Q05195 MXD1    HPRD  PubMed  
    P29590 P10242 MYB    HPRD  PubMed  
    P29590 P01106 MYC    HPRD  PubMed  
    P29590 O75376 NCOR1    HPRD  PubMed  
    P29590 Q9Y618 NCOR2    HPRD  PubMed  
    P29590 P22736 NR4A1    HPRD  PubMed  
    P29590 Q96IZ0 PAWR    HPRD  PubMed  
    P29590 PAX transcription domain interacting protein PAXIP1    HPRD  PubMed  
    P29590 P29590 PML    HPRD  PubMed  
    P29590 P10276 RARA    HPRD  PubMed  
    P29590 P06400 RB1    HPRD  PubMed  
    P29590 Q04206 RELA    HPRD  PubMed  
    P29590 P62913 RPL11    HPRD  PubMed  
    P29590 Q9HC62 SENP2    HPRD  PubMed  
    P29590 Q96ST3 SIN3A    HPRD  PubMed  
    P29590 P12755 SKI    HPRD  PubMed  
    P29590 P84022 SMAD3    HPRD  PubMed  
    P29590 P08047 SP1    HPRD  PubMed  
    P29590 P11831 SRF    HPRD  PubMed  
    P29590 P40763 STAT3    HPRD  PubMed  
    P29590 P63165 SUMO1    HPRD  PubMed  
    P29590 P61956 SUMO2    HPRD  PubMed  
    P29590 P55854 SUMO3    HPRD  PubMed  
    P29590 O43463 SUV39H1    HPRD  PubMed  
    P29590 Q13569 TDG    HPRD  PubMed  
    P29590 P36897 TGFBR1    HPRD  PubMed  
    P29590 P37173 TGFBR2    HPRD  PubMed  
    P29590 P10827 THRA    HPRD  PubMed  
    P29590 Q92547 TOPBP1    HPRD  PubMed  
    P29590 P04637 TP53    HPRD  PubMed  
    P29590 O15350 TP73    HPRD  PubMed  
    P29590 O15164 TRIM24    HPRD  PubMed  
    P29590 P14373 TRIM27    HPRD  PubMed  
    P29590 Q86WT6 TRIM69    HPRD  PubMed  
    P29590 Q05516 ZBTB16    HPRD  PubMed  
    P29590 O95405 ZFYVE9    HPRD  PubMed  
    BioGRID:111384 BioGRID:106637 ADH1B    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:117669 ANKRD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:108154 ARID3A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111384 BioGRID:115694 ARIH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:106898 ARNT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111384 BioGRID:107776 ATF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111384 BioGRID:110433 ATXN3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:120308 BANP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:107076 BCL6    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:115315 CASP8AP2    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:107343 CCNT1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex 
    BioGRID:111384 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111384 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111384 BioGRID:107456 CDK6    BioGRID  PubMed Biochemical Activity 
    BioGRID:111384 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:116369 CHEK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    NP_060693.1 CHFR    BIND  PubMed CHFR interacts an unspecified isoform of PML. 
    BioGRID:111384 BioGRID:120861 CHFR    BioGRID  PubMed FRET 
    BioGRID:111384 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:107837 CSNK1D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111384 BioGRID:129460 CSNK2A3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:107843 CSNK2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Two-hybrid 
    BioGRID:111384 BioGRID:971751 EBNA-1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:108223 ECT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:108292 EIF4E    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:108315 ELF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:108446 EZH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:117657 FBXO3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111384 BioGRID:108636 FOS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111384 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:108894 GATA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:109335 HHEX    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111384 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:111384 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:114390 IER3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:115000 IKBKE    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:118100 KLHL20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110269 MAF    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:110275 MAGEA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:112315 MAP2K4    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111586 MAPK11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:111581 MAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111584 MAPK7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111384 BioGRID:114833 MED7    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:119337 MRTO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:110845 NFATC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110857 NFKB1    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:113033 NR2C1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111384 BioGRID:109165 NR3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:971527 ORF23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:123893 PCBD2    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:114124 PIAS1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111384 BioGRID:114523 PIAS2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:111384 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:111332 PKM    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111384 BioGRID:111341 PLAGL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111384 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:111384 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:111384 BioGRID:111430 POLR2E    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:111464 PPARG    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111384 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111839 RANBP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:111384 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:115862 RBCK1    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111384 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111916 RFC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:971427 RL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:120146 RNF111    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111384 BioGRID:120281 RNF125    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:111974 RNF4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET 
    BioGRID:111384 BioGRID:112055 RPL11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:971429 RS1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111384 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:111384 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:107312 RUNX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112168 RXRA    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:941018 SAP25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:112211 SATB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:117517 SENP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:111384 BioGRID:115202 SETDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:113368 SF1    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:112352 SH3GL1    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:112372 SIAH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112373 SIAH2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:112397 SLC1A2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112481 SMARCA4    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:114805 SNRNP40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:112555 SP100    BioGRID  PubMed Co-localization; Two-hybrid 
    BioGRID:111384 BioGRID:112566 SPI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112600 SRF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111384 BioGRID:117059 SUZ12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:116830 SYNE2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:217772 Senp2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111384 BioGRID:112787 TCF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112855 TDG    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111384 BioGRID:119942 TERF2IP    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:112874 TERT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:112908 TGIF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111384 BioGRID:116256 TOPBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:115505 TOPORS    BioGRID  PubMed Co-localization 
    BioGRID:111384 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111384 BioGRID:114181 TP63    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111384 BioGRID:114333 TRIM24    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:126654 TRIM69    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111384 BioGRID:113177 UBE2I    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111384 BioGRID:118893 UHRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:1678066 UL123    BioGRID  PubMed Two-hybrid 
    BioGRID:111384 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111384 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:115684 YAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:113498 ZBTB16    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111384 BioGRID:114773 ZFYVE9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:113534 ZMYM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111384 BioGRID:136647 ZNF506    BioGRID  PubMed Co-localization 
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • DNA damage response, organism-specific biosystem (from WikiPathways)
      DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SUMO binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    cobalt ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    PML body organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PML body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    SMAD protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular senescence IDA
    Inferred from Direct Assay
    more info
    		  
    common-partner SMAD protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    maintenance of protein location in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of translation in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of histone deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of MHC class I biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		  
    response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PML body TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extrinsic to endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    protein PML
    Names
    protein PML
    RING finger protein 71
    promyelocytic leukemia protein
    tripartite motif protein TRIM19
    probable transcription factor PML
    promyelocytic leukemia, inducer of
    tripartite motif-containing protein 19

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029036.1 RefSeqGene

      Range
      5001..58147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002675.3 → NP_002666.1  protein PML isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (6, also known as PML-IV, PML-X and TRIM19zeta) contains a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BF510860, X63131
      Consensus CDS
      CCDS45297.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000378567, OTTHUMP00000249963, ENST00000395135, OTTHUMT00000421815
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 79
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 559
      Blast Score: 1088
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 88
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    2. NM_033238.2 → NP_150241.2  protein PML isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as TRIM19alpha).
      Source sequence(s)
      AB209411, AC013486, M79462, X63131
      Consensus CDS
      CCDS10255.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000268058, OTTHUMP00000174946, ENST00000268058, OTTHUMT00000269021
      Conserved Domains (4) summary
      cd00162
      Location:57 – 95
      Blast Score: 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 559
      Blast Score: 1107
      DUF3583; Protein of unknown function (DUF3583)
      smart00336
      Location:124 – 166
      Blast Score: 94
      BBOX; B-Box-type zinc finger
      cl10012
      Location:610 – 758
      Blast Score: 109
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    3. NM_033239.2 → NP_150242.1  protein PML isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (9, also known as PML-II and TRIM19kappa) contains a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC034251, X63131
      Consensus CDS
      CCDS10257.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000268059, OTTHUMP00000174962, ENST00000268059, OTTHUMT00000269039
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 83
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 570
      Blast Score: 1115
      DUF3583; Protein of unknown function (DUF3583)
      smart00336
      Location:124 – 166
      Blast Score: 91
      BBOX; B-Box-type zinc finger

    4. NM_033240.2 → NP_150243.2  protein PML isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BX647287, X63131
      Consensus CDS
      CCDS45298.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000395576, OTTHUMP00000249969, ENST00000435786, OTTHUMT00000421821
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 80
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 570
      Blast Score: 1107
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 88
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    5. NM_033244.3 → NP_150247.2  protein PML isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (5, also known as PML-3B, PML-VI and TRIM19epsilon) contains a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF230405, BC034251, X63131
      Consensus CDS
      CCDS45299.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000394642, OTTHUMP00000249968, ENST00000436891, OTTHUMT00000421820
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 78
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 555
      Blast Score: 1054
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 86
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    6. NM_033246.2 → NP_150249.1  protein PML isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (7, also known as PML-6B, PML-VIB, TRIM19eta and TRIM19iota) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BF510860, X63131
      Consensus CDS
      CCDS45300.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000353004, OTTHUMP00000249971, ENST00000359928, OTTHUMT00000421823
      Conserved Domains (3) summary
      pfam12126
      Location:240 – 418
      Blast Score: 724
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 80
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl15348
      Location:57 – 91
      Blast Score: 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    7. NM_033247.2 → NP_150250.2  protein PML isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (8, also known as PML-VII and TRIM19theta) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC034251, X63131
      Consensus CDS
      CCDS10256.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000378564, OTTHUMP00000174961, ENST00000395132, OTTHUMT00000269038
      Conserved Domains (3) summary
      pfam12126
      Location:240 – 418
      Blast Score: 721
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 81
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl15348
      Location:57 – 91
      Blast Score: 87
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    8. NM_033249.2 → NP_150252.1  protein PML isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (10, also known as PML-4A, PML-IVA and TRIM19lambda) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BF510860, X63131
      Consensus CDS
      CCDS58386.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000457023, OTTHUMP00000249970, ENST00000564428, OTTHUMT00000421822
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 77
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 511
      Blast Score: 1146
      DUF3583; Protein of unknown function (DUF3583)
      cl00034
      Location:124 – 166
      Blast Score: 86
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    9. NM_033250.2 → NP_150253.2  protein PML isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (11, also known as PML-2A and PML-IIA) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC034251, X63131
      Consensus CDS
      CCDS10258.1
      UniProtKB/Swiss-Prot
      P29590
      Related
      ENSP00000315434, OTTHUMP00000174963, ENST00000354026, OTTHUMT00000269040
      Conserved Domains (3) summary
      cd00162
      Location:57 – 95
      Blast Score: 81
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12126
      Location:240 – 522
      Blast Score: 1172
      DUF3583; Protein of unknown function (DUF3583)
      smart00336
      Location:124 – 166
      Blast Score: 90
      BBOX; B-Box-type zinc finger

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p10 Primary Assembly

      Range
      74287014..74340160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      51118849..51172183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018926.1 Alternate CHM1_1.0

      Range
      54335853..54388995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01038703.1 (4929..38117) None
    genomic ABBA01038704.1 None
    genomic AC013486.12 (37014..38061) None
    genomic AC108137.8 (131028..177015) None
    genomic AMYH01006780.1 (135226..188368) None
    genomic CH471082.1 EAW77946.1
      EAW77947.1
    genomic S51489.1 AAD13865.1
    genomic S68527.1 AAB29490.1
    genomic X64800.1 CAA46026.1
    mRNA AB208950.1 BAD92187.1
    mRNA AB209051.1 BAD92288.1
    mRNA AB209411.1 BAD92648.1
    mRNA AF230401.1 AAG50180.1
    mRNA AF230402.1 AAG50181.1
    mRNA AF230403.1 AAG50182.1
    mRNA AF230404.1 AAG50183.1
    mRNA AF230405.1 AAG50184.1
    mRNA AF230406.1 AAG50185.1
    mRNA AF230407.1 AAG50186.1
    mRNA AF230408.1 AAG50187.1
    mRNA AF230409.1 AAG50188.1
    mRNA AF230410.1 AAG50189.1
    mRNA AF230411.1 AAG50190.1
    mRNA AF370432.1 AAQ15268.1
    mRNA AK026871.1 None
    mRNA AK096663.1 None
    mRNA AK300256.1 BAG62021.1
    mRNA BC000080.2 AAH00080.2
    mRNA BC020994.2 AAH20994.1
    mRNA BC034251.1 None
    mRNA BC139795.1 AAI39796.1
    mRNA BF510860.1 None
    mRNA BT009911.1 AAP88913.1
    mRNA BX647287.1 None
    mRNA M73778.1 AAA60125.1
    mRNA M79462.1 AAA60388.1
    mRNA M79463.1 AAA60351.1
    mRNA M79464.1 AAA60390.1
    mRNA M80185.1 AAA60352.1
    mRNA S50913.1 AAB19601.2
    mRNA X63131.1 CAA44841.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29590.3 GenPept UniProtKB/Swiss-Prot:P29590

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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      • Order cDNA clone
        Order cDNA clone
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      • BioSystems
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
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        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
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        Genome records having the gene annotated on corresponding genomic reference sequence.
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        PubChem Compounds
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        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
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        Link to Nucleotide RefSeq RNAs
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        Link to Nucleotide RefSeqGenes
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        Related SNP records
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        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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