PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: PMAIP1provided by HGNC
Official Full Name: phorbol-12-myristate-13-acetate-induced protein 1provided by HGNC
Primary source: HGNC:9108
See related: Ensembl:ENSG00000141682; HPRD:12002; MIM:604959; Vega:OTTHUMG00000132765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APR; NOXA

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Genomic context

Location :: 18q21.32

Sequence :: Chromosome: 18; NC_000018.9 (57567192..57571538)

See PMAIP1 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
Title: Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
Bortezomib can enhance sensitivity of NB4 cells to apoptosis induced by As(2)O(3) which may be related to up-regulation of proapoptotic protein NOXA.
Title: [NB4 cell apoptosis induced by bortezomib combined with As(2)O(3) and its mechanism].
Noxa is critical for sensitivity to cell death induced by 2-deoxyglucose. This is the first evidence of the implication of a BH3-only protein in death induced by 2-DG.
Title: 2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma.
Noxa triggers the degradation of Mcl-1 at the mitochondria according to the exclusive location of Noxa at this compartment.
Title: Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.
Noxa/Mcl-1 balance is regulated by glucose deprivation as well as by general metabolic stress
Title: Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1.
A pathway leading from the detection of viral RNA during modified vaccinia virus infection by the cytosolic helicase-pathway, to the up-regulation of Noxa and apoptosis via IRF3 and type I IFN signalling.
Title: Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
Noxa participates in triggering mitochondrial dysfunction in multiple apoptotic pathways through distinct mechanisms
Title: Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.
Title: Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.
Expression of p53-inducible BH3-only apoptotic proteins Puma and Noxa was elevated and large activation of executive caspases was observed.
Title: Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA.
Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death, which represents a mechanism to limit the oncogenic potential of deregulated Ras signals.
Title: Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.

Submit: New GeneRIF Correction See all (49)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study of the metabolic syndrome in Indian Asian men.

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000018.8	NP_002458.1	MYC	BIND	PubMed	c-Myc interacts with NOXA promoter.
NC_000018.8	NP_003434.1	ZBTB17	BIND	PubMed	Miz1 interacts with NOXA promoter.
NP_066950.1	NP_004040.1	BCL2A1	BIND	PubMed	Noxa interacts with A1. This interaction was modelled on a demonstrated interaction between human Noxa and mouse A1.
Q13794	Q07814	BAX	HPRD	PubMed
Q13794	P10415	BCL2	HPRD	PubMed
Q13794	Q16548	BCL2A1	HPRD	PubMed
Q13794	Q07817	BCL2L1	HPRD	PubMed
Q13794	Q07820	MCL1	HPRD	PubMed
Q13794	P02775	PPBP	HPRD	PubMed
Q13794	Q05516	ZBTB16	HPRD	PubMed
BioGRID:111379	BioGRID:107057	BAX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111379	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:111379	BioGRID:107069	BCL2A1	BioGRID	PubMed	Protein-peptide
BioGRID:111379	BioGRID:107070	BCL2L1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:111379	BioGRID:107071	BCL2L2	BioGRID	PubMed	Protein-peptide
BioGRID:111379	BioGRID:109187	GSK3B	BioGRID	PubMed	Two-hybrid
BioGRID:111379	BioGRID:115385	HUWE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111379	BioGRID:110338	MCL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111379	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111379	BioGRID:113498	ZBTB16	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
activation of pro-apoptotic gene products	TAS Traceable Author Statement more info
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	TAS Traceable Author Statement more info
cellular component disassembly involved in apoptosis	IDA Inferred from Direct Assay more info	PubMed
cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info
cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis by intracellular signals	TAS Traceable Author Statement more info
negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of glucose metabolic process	IDA Inferred from Direct Assay more info
positive regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info
positive regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
positive regulation of protein oligomerization	IDA Inferred from Direct Assay more info	PubMed
positive regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
protein insertion into mitochondrial membrane involved in induction of apoptosis	IEA Inferred from Electronic Annotation more info
reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
regulation of mitochondrial membrane permeability	IDA Inferred from Direct Assay more info	PubMed
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
response to UV	IEA Inferred from Electronic Annotation more info
response to X-ray	IEA Inferred from Electronic Annotation more info
response to dsRNA	IDA Inferred from Direct Assay more info	PubMed
signal transduction by p53 class mediator resulting in induction of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
virus-infected cell apoptosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: phorbol-12-myristate-13-acetate-induced protein 1

Names: phorbol-12-myristate-13-acetate-induced protein 1; protein Noxa; PMA-induced protein 1; immediate-early-response protein APR; adult T cell leukemia-derived PMA-responsive

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021127.2 → NP_066950.1 phorbol-12-myristate-13-acetate-induced protein 1

Status: VALIDATED

Source sequence(s)

BC013120, BC032663, BF667112, BM999509

Consensus CDS

CCDS11975.1

UniProtKB/Swiss-Prot

Q13794

UniProtKB/TrEMBL

Q8N589

Related

ENSP00000326119, OTTHUMP00000163652, ENST00000316660, OTTHUMT00000256137

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

57567192..57571538

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

54276682..54281028

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC107990.5 (44657..48957)	None
genomic	CH471096.1 (12878880..12883182)	None
mRNA	AK311943.1	BAG34884.1
mRNA	BC013120.1	AAH13120.1
mRNA	BC032663.1	AAH32663.1
mRNA	BF667112.1	None
mRNA	BM999509.1	None
mRNA	D90070.1	BAA14111.1
other-genetic	JF432472.1	ADZ15689.1