PTOV1 prostate tumor overexpressed 1 [Homo sapiens] - Gene

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Summary

Official Symbol: PTOV1provided by HGNC
Official Full Name: prostate tumor overexpressed 1provided by HGNC
Primary source: HGNC:9632
Locus tag: PP642
See related: Ensembl:ENSG00000104960; HPRD:17929; MIM:610195
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACID2; PTOV-1; MGC71475; DKFZp586I111

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Genomic context

Location :: 19q13.33

Sequence :: Chromosome: 19; NC_000019.9 (50354416..50363999)

See PTOV1 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTOV1 expression is associated to more aggressive human carcinomas and more significantly to bladder carcinomas suggesting that this protein is a potential new marker of aggressive disease in the latter tumors.
Title: PTOV1 is overexpressed in human high-grade malignant tumors.
MED25 and PTOV1 differentially modulate retinoic acid sensitivity in cancer cells depending on their expression levels.
Title: PTOV1 antagonizes MED25 in RAR transcriptional activation.
PTOV1 is overexpressed in high-grade prostatic intraepithelial neoplasia associated with cancer and is a potential marker for studying the carcinogenesis and progression of prostate cancer.
Title: PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy.
PTOV1 assists flotillin-1 in its translocation to the nucleus and both proteins are required for cell proliferation.
Title: PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts.
This protein, overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle.
Title: PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
PTOV1	Q08495	EPB49	HPRD	PubMed
PTOV1	Q13526	PIN1	HPRD	PubMed
PTOV1	Q13813	SPTAN1	HPRD	PubMed
PTOV1	O75069	TMCC2	HPRD	PubMed
BioGRID:119792	BioGRID:114226	BECN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119792	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119792	BioGRID:108353	EPB49	BioGRID	PubMed	Two-hybrid
BioGRID:119792	BioGRID:111317	PIN1	BioGRID	PubMed	Two-hybrid
BioGRID:119792	BioGRID:109072	SFN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119792	BioGRID:112587	SPTAN1	BioGRID	PubMed	Two-hybrid
BioGRID:119792	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: prostate tumor-overexpressed gene 1 protein

Names: prostate tumor-overexpressed gene 1 protein; prostate tumor overexpressed gene 1; activator interaction domain-containing protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017432.3 → NP_059128.2 prostate tumor-overexpressed gene 1 protein

Status: PROVISIONAL

Source sequence(s)

AC018766, BC042921, DB496336

Consensus CDS

CCDS12782.1

UniProtKB/Swiss-Prot

Q86YD1

Related

ENSP00000375717, ENST00000391842

Conserved Domains (1) summary

pfam11232
Location:85 – 239
Blast Score: 668

Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

50354416..50363999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

46730759..46740340

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF238381.1	AAF70635.1
genomic	CH471177.1	EAW52552.1
		EAW52553.1
		EAW52554.1
		EAW52555.1
		EAW52556.1
		EAW52557.1
		EAW52558.1
		EAW52559.1
		EAW52560.1
		EAW52561.1
		EAW52562.1
mRNA	AF218026.1	AAG17268.1
mRNA	AJ617480.1	CAE84582.1
mRNA	AK057817.1	None
mRNA	AK294366.1	BAG57628.1
mRNA	AY358168.1	AAQ88535.1
mRNA	BC015172.1	AAH15172.1
mRNA	BC042921.1	AAH42921.1
mRNA	BC065486.1	None
mRNA	DB496336.1	None
mRNA	U79287.1	None