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    PLXNA1 plexin A1 [ Homo sapiens ]

    Gene ID: 5361, updated on 11-May-2012

    Summary

    Official Symbol
    PLXNA1provided by HGNC
    Official Full Name
    plexin A1provided by HGNC
    Primary source
    HGNC:9099
    See related
    Ensembl:ENSG00000114554; HPRD:11868; MIM:601055; Vega:OTTHUMG00000044222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121

    Genomic context

    Location :
    3q21.3
    Sequence :
    Chromosome: 3; NC_000003.11 (126707437..126756235)
    See PLXNA1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100132481 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene regulator of chromosome condensation 2 pseudogene 4 Neighboring gene chromosome 3 open reading frame 56 Neighboring gene proline rich 20B pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UIW2 P31749 AKT1    HPRD  PubMed  
    Q9UIW2 P07332 FES    HPRD  PubMed  
    Q9UIW2 O14786 NRP1    HPRD  PubMed  
    Q9UIW2 Q9UIW2 PLXNA1    HPRD  PubMed  
    Q9UIW2 O43157 PLXNB1    HPRD  PubMed  
    Q9UIW2 O00212 RHOD    HPRD  PubMed  
    Q9UIW2 Q92730 RND1    HPRD  PubMed  
    Q9UIW2 Q8NFY4 SEMA6D    HPRD  PubMed  
    BioGRID:111375 BioGRID:106710 AKT1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111375 BioGRID:109992 KDR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111375 BioGRID:110944 NPTX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111375 BioGRID:111375 PLXNA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111375 BioGRID:119010 RHOD    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111375 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    semaphorin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
     
    dichotomous subdivision of terminal units involved in salivary gland branching IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development TAS
    Traceable Author Statement
    more info
    PubMed 
    semaphorin-plexin signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    semaphorin receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    plexin-A1
    Names
    plexin-A1
    plexin 1
    semaphorin receptor NOV

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032242.3NP_115618.3  plexin-A1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011199, AI472001
      Consensus CDS
      CCDS33847.2
      UniProtKB/Swiss-Prot
      Q9UIW2
      Related
      ENSP00000377061, OTTHUMP00000215966, ENST00000393409, OTTHUMT00000356451
      Conserved Domains (8) summary
      cd01179
      Location:9611046
      Blast Score: 299
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:864960
      Blast Score: 301
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10481148
      Blast Score: 291
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam08337
      Location:13171866
      Blast Score: 2416
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      smart00630
      Location:51487
      Blast Score: 691
      Sema; semaphorin domain
      cd11271
      Location:38513
      Blast Score: 2421
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cl02601
      Location:514553
      Blast Score: 157
      PSI; Plexin repeat
      cl15674
      Location:11501232
      Blast Score: 105
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      126707437..126756235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      124086407..124135205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011199.22 (21828..70622) None
    genomic CH471052.2 EAW79349.1
      EAW79350.1
      EAW79351.1
    mRNA AI472001.1 None
    mRNA AK054675.1 None
    mRNA AK055605.1 None
    mRNA AK126101.1 BAC86440.1
    mRNA AK127254.1 None
    mRNA AK128612.1 BAG54700.1
    mRNA AK293425.1 BAG56931.1
    mRNA AL136663.1 None
    mRNA BC017323.2 None
    mRNA BC032432.1 None
    mRNA BC042904.1 None
    mRNA BQ920360.1 None
    mRNA X87832.2 CAB57274.1
    other-genetic BC156129.1 AAI56130.1
    other-genetic BC157020.1 AAI57021.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZTY7 GenPept UniProtKB/TrEMBL:Q6ZTY7
    Q9NSM6 GenPept UniProtKB/TrEMBL:Q9NSM6
    Q9UIW2.3 GenPept UniProtKB/Swiss-Prot:Q9UIW2

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