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PLS1 plastin 1 [ Homo sapiens (human) ]

Gene ID: 5357, updated on 7-Aug-2014
Official Symbol
PLS1provided by HGNC
Official Full Name
plastin 1provided by HGNC
Primary source
HGNC:9090
See related
Ensembl:ENSG00000120756; HPRD:04110; MIM:602734; Vega:OTTHUMG00000159292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
See PLS1 in Epigenomics, MapViewer
Location:
3q23
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (142596387..142713664)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142315229..142432506)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 143 Neighboring gene ribosomal protein L6 pseudogene 9 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene ribosomal protein L8 pseudogene 3

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with plastin 1 (PLS1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
plastin-1
Names
plastin-1
fimbrin
I plastin
intestine specific plastin
intestine-specific plastin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145319.1NP_001138791.1  plastin-1

    See proteins identical to NP_001138791.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the more predominant transcript. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA933088, AK290316, BM263745, DA427212, L20826
    Consensus CDS
    CCDS3125.1
    UniProtKB/Swiss-Prot
    Q14651
    Related
    ENSP00000387890, OTTHUMP00000214728, ENST00000457734, OTTHUMT00000354434
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain
  2. NM_001172312.1NP_001165783.1  plastin-1

    See proteins identical to NP_001165783.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC072028, BC031083, CB240816
    Consensus CDS
    CCDS3125.1
    UniProtKB/Swiss-Prot
    Q14651
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain
  3. NM_002670.2NP_002661.2  plastin-1

    See proteins identical to NP_002661.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA933088, AK290316, BM263745, BP262012, L20826
    Consensus CDS
    CCDS3125.1
    UniProtKB/Swiss-Prot
    Q14651
    Related
    ENSP00000336831, OTTHUMP00000214729, ENST00000337777, OTTHUMT00000354435
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    142596387..142713664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713660.1XP_006713723.1  

    See proteins identical to XP_006713723.1

    UniProtKB/Swiss-Prot
    Q14651
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain
  2. XM_006713661.1XP_006713724.1  

    See proteins identical to XP_006713724.1

    UniProtKB/Swiss-Prot
    Q14651
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain
  3. XM_006713662.1XP_006713725.1  

    See proteins identical to XP_006713725.1

    UniProtKB/Swiss-Prot
    Q14651
    Conserved Domains (5) summary
    smart00033
    Location:399502
    Blast Score: 175
    CH; Calponin homology domain
    COG5069
    Location:13621
    Blast Score: 683
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:123238
    Blast Score: 239
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1581
    Blast Score: 178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:519624
    Blast Score: 150
    CH; Calponin homology (CH) domain

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    139687922..139805221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    142278265..142395516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)