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    katanin-60 katanin 60 [ Drosophila melanogaster ]

    Gene ID: 53566, updated on 10-May-2012
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    Summary

    Official Symbol
    katanin-60provided by Flybase
    Official Full Name
    katanin 60provided by Flybase
    Primary source
    FLYBASE:FBgn0040208
    Locus tag
    Dmel_CG10229
    Gene type
    protein coding
    RNA name
    katanin 60
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10229; DmCG10229; Dmel\CG10229; kat60; Katanin 60; Katanin-60; katanin60-dm
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    Genomic context

    Location :
    82F6-82F6
    Sequence :
    Chromosome: 3R; NT_033777.2 (1053011..1057940, complement)
    See katanin-60 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG2604 gene product from transcript CG2604-RC Neighboring gene CG14664 gene product from transcript CG14664-RA Neighboring gene CG1115 gene product from transcript CG1115-RC Neighboring gene CG12005 gene product from transcript CG12005-RB Neighboring gene CG12163 gene product from transcript CG12163-RB Neighboring gene retinophilin Neighboring gene CG33293 gene product from transcript CG33293-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Drosophila katanin-60 depolymerizes and severs at microtubule defects. Díaz-Valencia JD, et al. Biophys J, 2011 May 18. PMID 21575578.
    2. Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration. Zhang D, et al. Nat Cell Biol, 2011 Apr. PMID 21378981.
    3. Transcriptional regulation by CHIP/LDB complexes. Bronstein R, et al. PLoS Genet, 2010 Aug 12. PMID 20730086.
    4. Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. Widmann TJ, et al. J Cell Sci, 2009 May 1. PMID 19366729.
    5. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cuttell L, et al. Cell, 2008 Oct 31. PMID 18984163.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Katanin (p60), believed to be the first discovered severing enzyme, binds and severs microtubules via single molecule total internal reflection fluorescence microscopy.
      Title: Drosophila katanin-60 depolymerizes and severs at microtubule defects.
    2. Data suggest that Drosophila Katanin 60 removes tubulin from microtubule lattice or microtubule ends that contact specific cortical sites to prevent stable and/or lateral attachments.
      Title: Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration.
    3. Katanin appears to function primarily on anaphase chromosomes, where it stimulates microtubule plus-end depolymerization and Pacman-based chromatid motility.
      Title: Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:72797 BioGRID:62391 BEAF-32    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:67905 CG11771    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:61438 CG7856    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:66871 CycC    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:57686 MED18    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:65180 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:64105 Ubp64E    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:58923 kat80    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:72797 katanin-60    BioGRID  PubMed Two-hybrid 
    BioGRID:72797 BioGRID:62296 shot    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the katanin-60 gene: The katanin-60 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chaeta development IGI
    Inferred from Genetic Interaction
    more info
    		  
    microtubule severing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    microtubule severing NAS
    Non-traceable Author Statement
    more info
    		  
    microtubule-based process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    wing disc development IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    katanin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    katanin complex NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG10229 gene product from transcript CG10229-RA
    Names
    CG10229-PA
    katanin
    katanin 60
    katanin-60-PA
    NP_524997.2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      1053011..1057940, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080258.3 → NP_524997.2  katanin 60 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN89
      Related
      FBpp0078469
      Conserved Domains (4) summary
      cd00009
      Location:323 – 462
      Blast Score: 258
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:325 – 463
      Blast Score: 201
      AAA; ATPases associated with a variety of cellular activities
      pfam09336
      Location:537 – 570
      Blast Score: 98
      Vps4_C; Vps4 C terminal oligomerisation domain
      cl09099
      Location:292 – 348
      Blast Score: 104
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF52059.2
    mRNA BT133173.1 AEZ68801.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN89.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content