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    PLRG1 pleiotropic regulator 1 [ Homo sapiens ]

    Gene ID: 5356, updated on 11-May-2012
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    Summary

    Official Symbol
    PLRG1provided by HGNC
    Official Full Name
    pleiotropic regulator 1provided by HGNC
    Primary source
    HGNC:9089
    See related
    Ensembl:ENSG00000171566; HPRD:16181; MIM:605961; Vega:OTTHUMG00000161411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRL1; PRP46; PRPF46; MGC110980
    Summary
    This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
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    Genomic context

    Location :
    4q31.2-q32.1
    Sequence :
    Chromosome: 4; NC_000004.11 (155456149..155471585, complement)
    See PLRG1 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene dachsous 2 (Drosophila) Neighboring gene kelch domain containing 4 pseudogene Neighboring gene WD repeat domain 77 pseudogene Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene fibrinogen beta chain

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. Ganesh K, et al. J Biol Chem, 2011 May 13. PMID 21385873.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Study includes the isolation of a cDNA encoding the human PRL1 homolog.
      Title: Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis.
    2. A central region in hnRNP-M is required for interaction with CDC5L/PLRG1.
      Title: Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
    3. the interaction between CDC5L and PLRG1 is essential for pre-mRNA splicing
      Title: Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002660.1 NP_001244.1 CDC5L    BIND  PubMed CDC5L interacts with PLRG1. 
    O43660 Q99459 CDC5L    HPRD  PubMed  
    BioGRID:111370 BioGRID:115575 BCAS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Protein-peptide; Reconstituted Complex 
    BioGRID:111370 BioGRID:120000 CPVL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:121123 CTNNBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:214866 Cdc5l    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:110034 KPNA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111370 BioGRID:110036 KPNA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111370 BioGRID:118151 PRPF19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:228650 Prpf8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:211406 Snw1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:123904 USP42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111370 BioGRID:129825 ZSCAN1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PLRG1 gene: The PLRG1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    signal transducer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    pleiotropic regulator 1
    Names
    pleiotropic regulator 1
    pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201564.1 → NP_001188493.1  pleiotropic regulator 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC107385, AK002108, AW291931, BC020786, BP314297
      Consensus CDS
      CCDS56341.1
      UniProtKB/Swiss-Prot
      O43660
      Related
      ENSP00000303191, OTTHUMP00000220178, ENST00000302078, OTTHUMT00000364826
      Conserved Domains (1) summary
      cd00200
      Location:187 – 481
      Blast Score: 638
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_002669.3 → NP_002660.1  pleiotropic regulator 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC107385, AW291931, BC106004, BP314297
      Consensus CDS
      CCDS34083.1
      UniProtKB/Swiss-Prot
      O43660
      Related
      ENSP00000424417, OTTHUMP00000220176, ENST00000499023, OTTHUMT00000364824
      Conserved Domains (1) summary
      cd00200
      Location:196 – 490
      Blast Score: 642
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      155456149..155471585, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      151196830..151212267, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107385.4 (11078..26107) None
    genomic CH471056.2 EAX04940.1
      EAX04941.1
    mRNA AF044333.1 AAD09407.1
    mRNA AK002108.1 BAG51016.1
    mRNA AK304574.1 BAH14218.1
    mRNA AK307997.1 None
    mRNA AW291931.1 None
    mRNA BC020786.1 AAH20786.1
    mRNA BC036046.1 None
    mRNA BC106004.1 AAI06005.1
    mRNA BP314297.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43660.1 GenPept UniProtKB/Swiss-Prot:O43660
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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