HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: HMGCLL1provided by VGNC
Official Full Name: 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1provided by VGNC
Primary source: VGNC:VGNC:29878
See related: BGD:BT13729; Ensembl:ENSBTAG00000025718
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (4789437..4989143)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA lyase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ketone body biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Names: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1

NP_001178122.1

EC 4.1.3.4

XP_005223314.1

EC 4.1.3.4

XP_005223315.1

EC 4.1.3.4

XP_059736377.1

EC 4.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191193.1 → NP_001178122.1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Status: PROVISIONAL

Source sequence(s)

NKLS02000023

Conserved Domains (2) summary

PLN02746
Location:41 → 336

PLN02746; hydroxymethylglutaryl-CoA lyase

pfam00682
Location:48 → 321

HMGL-like; HMGL-like

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

Range

4789437..4989143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005223257.5 → XP_005223314.1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_005223314.1

UniProtKB/TrEMBL

E1BK37

Related

ENSBTAP00000019954.5, ENSBTAT00000019954.7

Conserved Domains (1) summary

PLN02746
Location:41 → 336

PLN02746; hydroxymethylglutaryl-CoA lyase
XM_005223258.4 → XP_005223315.1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A3Q1MQ25

Related

ENSBTAP00000074065.1, ENSBTAT00000069672.2

Conserved Domains (1) summary

PLN02746
Location:41 → 304

PLN02746; hydroxymethylglutaryl-CoA lyase
XM_059880394.1 → XP_059736377.1 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X3