Spt5 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Spt5provided by Flybase
Primary source: FLYBASE:FBgn0040273
Locus tag: Dmel_CG7626
Gene type: protein coding
RNA name: Spt5
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7626; dDSIF; Dmel\CG7626; DSIF; dSpt5; Dspt5; spt5; SPT5

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Genomic context

Location :: 56D5-56D7

Sequence :: Chromosome: 2R; NT_033778.3 (15324991..15329403)

See Spt5 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Spt5 acts both positively and negatively on transcription in vivo during heat shock induction.
Title: Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:72729	BioGRID:59647	Axud1	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:72850	CG18764	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:73196	CG30497	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:65869	CG31550	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:66215	CG8159	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:64171	D19A	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:64170	D19B	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:61232	Hakai	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:65607	Rab26	BioGRID	PubMed	Two-hybrid
BioGRID:72729	BioGRID:63331	Rrp4	BioGRID	PubMed	Affinity Capture-Western

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General gene information

Pathways from BioSystems

Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
Formation of the Early Elongation Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mRNA Capping, organism-specific biosystem (from REACTOME)
mRNA Capping, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mRNA processing, organism-specific biosystem (from WikiPathways)
mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' pol...

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
mitotic cell cycle G2/M transition DNA damage checkpoint	IGI Inferred from Genetic Interaction more info
mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription elongation from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
colocalizes_with nuclear exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info
polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG7626 gene product from transcript CG7626-RA

Names: CG7626-PA; Spt5; Spt5-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

15324991..15329403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_144353.3 → NP_652610.1 Spt5 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V460

Related

FBpp0085716, FBtr0086531

Conserved Domains (5) summary

COG5164
Location:380 – 887
Blast Score: 460

SPT5; Transcription elongation factor [Transcription]

cd09888
Location:215 – 302
Blast Score: 345

NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)

cl00354
Location:743 – 773
Blast Score: 81

KOW; KOW motif

pfam11942
Location:134 – 209
Blast Score: 141

Spt5_N; Spt5 transcription elongation factor, acidic N-terminal

cl15277
Location:802 – 913
Blast Score: 210

Nucleoporin_FG; Nucleoporin FG repeat region