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ACXB Adenylyl cyclase X B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53427, updated on 11-Apr-2024

Summary

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Official Symbol
ACXBprovided by FlyBase
Official Full Name
Adenylyl cyclase X Bprovided by FlyBase
Primary source
FLYBASE:FBgn0040509
Locus tag
Dmel_CG17174
See related
AllianceGenome:FB:FBgn0040509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC; Ac34A; AC34A; CG17174; DACXB; Dmel\CG17174
Summary
Predicted to enable adenylate cyclase activity. Involved in spermatogenesis. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in adult head; organism; pre-elongation spermatid; and spermatocyte. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACXB in Genome Data Viewer
Location:
34A2-34A2; 2-47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12916814..12921008)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12916814..12921008)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44971 Neighboring gene Adenylyl cyclase X C Neighboring gene Adenylyl cyclase X A Neighboring gene Adenylyl cyclase X E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Levin LR, et al. Cell, 1992 Feb 7. PMID 1739965
  2. A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. Yovell Y, et al. J Neurochem, 1992 Nov. PMID 1402918
  3. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
  4. E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila. Duvall LB, et al. J Biol Rhythms, 2013 Aug. PMID 23929551, Free PMC Article
  5. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenylyl cyclase X B
Names
ACXB-PA
CG17174-PA
adenylyl cyclase
adenylyl cyclase 34A
NP_620474.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12916814..12921008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138989.3 → NP_620474.2  adenylyl cyclase X B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_620474.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NJA1, Q9VK52
    Related
    FBpp0079995
    Conserved Domains (3) summary
    smart00044
    Location:249 → 459
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam16214
    Location:36 → 276
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cl11967
    Location:298 → 484
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NJA1 Q9NJA1
Q9VK52 Q9VK52

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