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PLG plasminogen [ Homo sapiens (human) ]

Gene ID: 5340, updated on 27-Sep-2014
Official Symbol
PLGprovided by HGNC
Official Full Name
plasminogenprovided by HGNC
Primary source
HGNC:HGNC:9071
Locus tag
RP1-81D8.1
See related
Ensembl:ENSG00000122194; HPRD:01417; MIM:173350; Vega:OTTHUMG00000015957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Location:
6q26
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (160702193..160754054)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161123225..161175086)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lipoprotein, Lp(a)-like 2, pseudogene Neighboring gene lipoprotein, Lp(a) Neighboring gene uncharacterized LOC102724087 Neighboring gene mitogen-activated protein kinase kinase kinase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Plasminogen deficiency, type I
MedGen: C1968804 OMIM: 217090 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp779M0222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type peptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
extracellular matrix disassembly IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
fibrinolysis TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-cell adhesion mediated by cadherin TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
plasminogen
Names
plasminogen
plasmin
NP_000292.1
NP_001161810.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016200.1 

    Range
    5001..56862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000301.3NP_000292.1  plasminogen isoform 1 precursor

    See proteins identical to NP_000292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109933, DR004070, M74220, X05199
    Consensus CDS
    CCDS5279.1
    UniProtKB/Swiss-Prot
    P00747
    Conserved Domains (4) summary
    smart00020
    Location:580803
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:102182
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:581804
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01099
    Location:3897
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
  2. NM_001168338.1NP_001161810.1  plasminogen isoform 2 precursor

    See proteins identical to NP_001161810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AL109933, DR004070
    Consensus CDS
    CCDS55074.1
    UniProtKB/TrEMBL
    Q5TEH5
    Related
    ENSP00000355891, OTTHUMP00000017545, ENST00000366924, OTTHUMT00000042960
    Conserved Domains (2) summary
    cd01099
    Location:3897
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    cl00100
    Location:102136
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    160702193..160754054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    158568041..158620052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    161385876..161437750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)