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PLD2 phospholipase D2 [ Homo sapiens (human) ]

Gene ID: 5338, updated on 25-Jul-2014
Official Symbol
PLD2provided by HGNC
Official Full Name
phospholipase D2provided by HGNC
Primary source
HGNC:9068
See related
Ensembl:ENSG00000129219; HPRD:03857; MIM:602384; Vega:OTTHUMG00000090779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
See PLD2 in Epigenomics, MapViewer
Location:
17p13.1
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (4807101..4823432)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4710396..4726727)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 6 Neighboring gene misshapen-like kinase 1 Neighboring gene ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c pseudogene 1 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor, nicotinic, epsilon (muscle)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
G-protein coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
phospholipase D2
Names
phospholipase D2
PLD1C
hPLD2
choline phosphatase 2
phosphatidylcholine-hydrolyzing phospholipase D2
NP_001230037.1
NP_002654.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029608.1 

    Range
    5001..21332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243108.1NP_001230037.1  phospholipase D2 isoform PLD2B

    See proteins identical to NP_001230037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (PLD2B) has the same N- and C-termini but is shorter compared to isoform PLD2A.
    Source sequence(s)
    AF033850, AF038440, AF038441, BC015033, DA390950, DC407587
    Consensus CDS
    CCDS58507.1
    UniProtKB/Swiss-Prot
    O14939
    Related
    ENSP00000459571, OTTHUMP00000258108, ENST00000572940, OTTHUMT00000439787
    Conserved Domains (5) summary
    cd09843
    Location:335475
    Blast Score: 767
    PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
    cd09845
    Location:614795
    Blast Score: 975
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:66907
    Blast Score: 1523
    PLN02866; phospholipase D
    cd01254
    Location:180309
    Blast Score: 433
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62192
    Blast Score: 615
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_002663.4NP_002654.3  phospholipase D2 isoform PLD2A

    See proteins identical to NP_002654.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (PLD2A).
    Source sequence(s)
    AF033850, AF038440, BC015033, DA390950, DC407587
    Consensus CDS
    CCDS11057.1
    UniProtKB/Swiss-Prot
    O14939
    Related
    ENSP00000263088, OTTHUMP00000115984, ENST00000263088, OTTHUMT00000207561
    Conserved Domains (5) summary
    cd09843
    Location:335475
    Blast Score: 767
    PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
    cd09845
    Location:614795
    Blast Score: 975
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:66918
    Blast Score: 1568
    PLN02866; phospholipase D
    cd01254
    Location:180309
    Blast Score: 432
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62192
    Blast Score: 613
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    4807101..4823432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256695.1XP_005256752.1  

    Conserved Domains (3) summary
    cd01254
    Location:180309
    Blast Score: 429
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62192
    Blast Score: 608
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl15239
    Location:335475
    Blast Score: 759
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  2. XM_006721548.1XP_006721611.1  

    Conserved Domains (4) summary
    cd09845
    Location:471652
    Blast Score: 973
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    cd01254
    Location:37166
    Blast Score: 430
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:149
    Blast Score: 227
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl15239
    Location:192332
    Blast Score: 765
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  3. XM_006721547.1XP_006721610.1  

    See proteins identical to XP_006721610.1

    UniProtKB/Swiss-Prot
    O14939
    Conserved Domains (5) summary
    cd09843
    Location:335475
    Blast Score: 767
    PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
    cd09845
    Location:614795
    Blast Score: 975
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:66918
    Blast Score: 1568
    PLN02866; phospholipase D
    cd01254
    Location:180309
    Blast Score: 432
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62192
    Blast Score: 613
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  4. XM_005256696.1XP_005256753.1  

    Conserved Domains (2) summary
    cd09845
    Location:229410
    Blast Score: 970
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    cl15239
    Location:190
    Blast Score: 477
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  5. XM_005256697.1XP_005256754.1  

    Conserved Domains (3) summary
    cd09845
    Location:194375
    Blast Score: 973
    PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
    PLN02866
    Location:7498
    Blast Score: 1085
    PLN02866; phospholipase D
    cl15239
    Location:755
    Blast Score: 255
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    4598848..4615181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    4719366..4735679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)