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    PLD2 phospholipase D2 [ Homo sapiens (human) ]

    Gene ID: 5338, updated on 15-Jun-2013
    Official Symbol
    PLD2provided by HGNC
    Official Full Name
    phospholipase D2provided by HGNC
    Primary source
    HGNC:9068
    See related
    Ensembl:ENSG00000129219; HPRD:03857; MIM:602384; Vega:OTTHUMG00000090779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
    Location :
    17p13.1
    Sequence :
    Chromosome: 17; NC_000017.10 (4710396..4726727)
    See PLD2 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein domain containing 2 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 6 Neighboring gene misshapen-like kinase 1 Neighboring gene ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c pseudogene 1 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor, nicotinic, epsilon (muscle)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells. Ye Q, et al. J Biol Chem, 2013 Apr 5. PMID 23404507.
    2. Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion. Ye Q, et al. J Mol Biol, 2013 Feb 22. PMID 23238254.
    3. Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1. Chen F, et al. J Lipid Res, 2013 Feb. PMID 23213138.
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    5. Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells. Choi HJ, et al. Biochim Biophys Acta, 2012 Jun. PMID 22504301.

    See all (111) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FIC1 signals to FXR via a signaling pathway including PLD2 and PKCzeta
      Title: Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1.
    2. analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells
      Title: A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.
    3. Data indicate that the invasive phenotype of MDA-MB-231 cells is mediated by phospholipase D2 (PLD2) under direct regulation of both Janus kinase 3 (JAK3) and tepidermal growth factor receptor (EGFR).
      Title: Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.
    4. PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways.
      Title: Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells.
    5. how PLD2 participates in cell differentiation
      Title: Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action.
    6. The rhPLD2 may suppress the chronic inflammatory reaction through down-regulating PKC expression and STAT1/STAT5a activity in the lung. The rhPLD2 may be a suitable therapeutic target for asthma.
      Title: rhPLD2 suppresses chronic inflammation reactions in a guinea pig asthma model.
    7. the C-terminal domain of PLD2 can regulate Casein Kinase II by accelerating Casein Kinase II beta degradation.
      Title: The C-terminal domain of PLD2 participates in degradation of protein kinase CKII β subunit in human colorectal carcinoma cells.
    8. Host cell PLD1 and PLD2 accompanied A. fumigatus conidia during internalization.
      Title: β-1,3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cells.
    9. The PX domain of PLD2 mediates the interaction and has a GEF-like activity for RhoA, which contributes to stress fiber formation.
      Title: Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA.
    10. A high level of cell invasiveness of cancer cells can be explained for the first time by combined high JAK3/PLD2 phosphorylation and activity involving PLD2's Y415 residue, which might constitute a novel target to inhibit cancer cell invasion.
      Title: Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).
    Submit: New GeneRIF Correction See all (68)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002654.2 NP_005219.2 EGFR    BIND  PubMed EGFR interacts with PLD1. This interaction was modelled on a demonstrated interaction between human EGFR and mouse PLD2. 
    NP_002654.2 NP_002651.2 PLCG1    BIND  PubMed PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2. 
    O14939 P60709 ACTB    HPRD  PubMed  
    O14939 P12814 ACTN1    HPRD  PubMed  
    O14939 P04075 ALDOA    HPRD  PubMed  
    O14939 P09972 ALDOC    HPRD  PubMed  
    O14939 P49418 AMPH    HPRD  PubMed  
    O14939 Q92482 AQP3    HPRD  PubMed  
    O14939 P84077 ARF1    HPRD  PubMed  
    O14939 O00499 BIN1    HPRD  PubMed  
    O14939 Q03135 CAV1    HPRD  PubMed  
    O14939 P41240 CSK    HPRD  PubMed  
    O14939 Q16555 DPYSL2    HPRD  PubMed  
    O14939 P00533 EGFR    HPRD  PubMed  
    O14939 P06241 FYN    HPRD  PubMed  
    O14939 P04406 GAPDH    HPRD  PubMed  
    O14939 P17900 GM2A    HPRD  PubMed  
    O14939 P06239 LCK    HPRD  PubMed  
    O14939 P42345 MTOR    HPRD  PubMed  
    O14939 P35372 OPRM1    HPRD  PubMed  
    O14939 Q15121 PEA15    HPRD  PubMed  
    O14939 Q99755 PIP5K1A    HPRD  PubMed  
    O14939 P19174 PLCG1    HPRD  PubMed  
    O14939 P17252 PRKCA    HPRD  PubMed  
    O14939 Q05655 PRKCD    HPRD  PubMed  
    O14939 Raptor RPTOR    HPRD  PubMed  
    O14939 P61764 STXBP1    HPRD  PubMed  
    BioGRID:111354 BioGRID:106728 ALDOA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111354 BioGRID:106770 AMPH    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:111354 BioGRID:106856 AQP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:106870 ARF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111354 BioGRID:249680 Actb    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111354 BioGRID:106771 BIN1    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex 
    BioGRID:111354 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:111354 BioGRID:107306 CAV2    BioGRID  PubMed Co-fractionation 
    BioGRID:111354 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111354 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111354 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:111033 OPRM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:114230 PEA15    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111354 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111354 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:121582 RPTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111354 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111354 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAPE-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
    		  
    G-protein coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    glycerophospholipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylglycerol biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    brush border membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    phospholipase D2
    Names
    phospholipase D2
    PLD1C
    hPLD2
    choline phosphatase 2
    phosphatidylcholine-hydrolyzing phospholipase D2
    NP_001230037.1
    NP_002654.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029608.1 RefSeqGene

      Range
      5001..21332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243108.1 → NP_001230037.1  phospholipase D2 isoform PLD2B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (PLD2B) has the same N- and C-termini but is shorter compared to isoform PLD2A.
      Source sequence(s)
      AF033850, AF038440, AF038441, BC015033, DA390950, DC407587
      Consensus CDS
      CCDS58507.1
      UniProtKB/TrEMBL
      I3L2C9
      UniProtKB/Swiss-Prot
      O14939
      Related
      ENSP00000459571, OTTHUMP00000258108, ENST00000572940, OTTHUMT00000439787
      Conserved Domains (4) summary
      cd07297
      Location:62 – 192
      Blast Score: 608
      PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
      cd09843
      Location:335 – 475
      Blast Score: 740
      PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
      cd09845
      Location:614 – 795
      Blast Score: 978
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      cl00273
      Location:206 – 308
      Blast Score: 264
      PH-like; Pleckstrin homology-like domain

    2. NM_002663.4 → NP_002654.3  phospholipase D2 isoform PLD2A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (PLD2A).
      Source sequence(s)
      AF033850, AF038440, BC015033, DA390950, DC407587
      Consensus CDS
      CCDS11057.1
      UniProtKB/Swiss-Prot
      O14939
      Related
      ENSP00000263088, OTTHUMP00000115984, ENST00000263088, OTTHUMT00000207561
      Conserved Domains (4) summary
      cd07297
      Location:62 – 192
      Blast Score: 607
      PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
      cd09843
      Location:335 – 475
      Blast Score: 740
      PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
      cd09845
      Location:614 – 795
      Blast Score: 978
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      cl00273
      Location:206 – 308
      Blast Score: 264
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      4710396..4726727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      4598848..4615181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      4697020..4713333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01054775.1 (22476..38809) None
    genomic AC109333.28 (28693..44995) None
    genomic AC233723.2 (112239..128545) None
    genomic AMYH01008042.1 (97614..113927) None
    genomic CH471108.2 EAW90404.1
      EAW90405.1
      EAW90406.1
    mRNA AF033850.1 AAD04197.1
    mRNA AF035483.1 AAC24498.1
    mRNA AF038440.1 AAB96655.1
    mRNA AF038441.1 AAB96656.1
    mRNA AK304246.1 BAH14141.1
    mRNA AK314797.1 None
    mRNA AY178289.1 AAO21120.1
    mRNA BC015033.1 AAH15033.1
    mRNA BC056871.1 AAH56871.1
    mRNA DA390950.1 None
    mRNA DC407587.1 None
    mRNA AB209374.1 BAD92611.1
    other-genetic AM393149.1 CAL38027.1
    other-genetic AM393150.1 CAL38028.1
    other-genetic AM393159.1 CAL38037.1
    other-genetic AM393603.1 CAL38479.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14939.2 GenPept UniProtKB/Swiss-Prot:O14939

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
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      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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