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PLD1 phospholipase D1, phosphatidylcholine-specific [ Homo sapiens (human) ]

Gene ID: 5337, updated on 22-Nov-2014
Official Symbol
PLD1provided by HGNC
Official Full Name
phospholipase D1, phosphatidylcholine-specificprovided by HGNC
Primary source
HGNC:HGNC:9067
See related
Ensembl:ENSG00000075651; HPRD:03855; MIM:602382; Vega:OTTHUMG00000156947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
See PLD1 in Epigenomics, MapViewer
Location:
3q26
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (171600405..171810494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171318195..171528284, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene microRNA 569 Neighboring gene uncharacterized LOC102724479 Neighboring gene transmembrane protein 212 Neighboring gene fibronectin type III domain containing 3B Neighboring gene uncharacterized LOC101928615

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phosphatidylcholine-specific phospholipase D1 (PLD1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phospholipase D1
Names
phospholipase D1
choline phosphatase 1
phosphatidylcholine-hydrolyzing phospholipase D1
NP_001123553.1
NP_002653.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029851.1 

    Range
    5001..215090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130081.2NP_001123553.1  phospholipase D1 isoform b

    See proteins identical to NP_001123553.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini, but is shorter compared to isoform a.
    Source sequence(s)
    AB209907, DA464847
    Consensus CDS
    CCDS46957.1
    UniProtKB/TrEMBL
    Q59EA4
    Related
    ENSP00000348681, OTTHUMP00000211117, ENST00000356327, OTTHUMT00000346777
    Conserved Domains (5) summary
    cd07296
    Location:78209
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:352502
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:716897
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:821021
    PLN02866; phospholipase D
    cd01254
    Location:197326
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  2. NM_002662.4NP_002653.1  phospholipase D1 isoform a

    See proteins identical to NP_002653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB209907, BC068976, DA464847
    Consensus CDS
    CCDS3216.1
    UniProtKB/Swiss-Prot
    Q13393
    UniProtKB/TrEMBL
    Q59EA4
    Related
    ENSP00000342793, OTTHUMP00000211094, ENST00000351298, OTTHUMT00000346730
    Conserved Domains (5) summary
    cd07296
    Location:78209
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:352502
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:821059
    PLN02866; phospholipase D
    cd01254
    Location:197326
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    168688221..168898341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    171600405..171810494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247534.1XP_005247591.1  

    See proteins identical to XP_005247591.1

    UniProtKB/Swiss-Prot
    Q13393
    Conserved Domains (5) summary
    cd07296
    Location:78209
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:352502
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:716897
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:821021
    PLN02866; phospholipase D
    cd01254
    Location:197326
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  2. XM_005247533.1XP_005247590.1  

    See proteins identical to XP_005247590.1

    UniProtKB/Swiss-Prot
    Q13393
    Conserved Domains (5) summary
    cd07296
    Location:78209
    PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
    cd09842
    Location:352502
    PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
    cd09844
    Location:754935
    PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
    PLN02866
    Location:821059
    PLN02866; phospholipase D
    cd01254
    Location:197326
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    171281084..171491135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)