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ZFYVE1 zinc finger FYVE-type containing 1 [ Homo sapiens (human) ]

Gene ID: 53349, updated on 26-May-2016
Official Symbol
ZFYVE1provided by HGNC
Official Full Name
zinc finger FYVE-type containing 1provided by HGNC
Primary source
HGNC:HGNC:13180
See related
Ensembl:ENSG00000165861 HPRD:12017; MIM:605471; Vega:OTTHUMG00000171365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172
Summary
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Orthologs
Location:
14q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (72969445..73027212, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73436152..73493920, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene transfer RNA-Cys (GCA) 8-1 Neighboring gene ribosomal protein S12 pseudogene 1 Neighboring gene uncharacterized LOC105370560 Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA binding motif protein 25

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1589

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
ER-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
pre-autophagosomal structure IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
zinc finger FYVE domain-containing protein 1
Names
double FYVE-containing protein 1
phosphoinositide-binding protein SR3
protein phosphatase 1, regulatory subunit 172
tandem FYVE fingers-1 protein
zinc finger protein, subfamily 2A, member 1
zinc finger, FYVE domain containing 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281734.1NP_001268663.1  zinc finger FYVE domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001268663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL442663, BC014902, DA324499, DB059103, EL734498, HY248287
    Consensus CDS
    CCDS61498.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000326921, OTTHUMP00000245916, ENST00000318876, OTTHUMT00000413171
    Conserved Domains (3) summary
    cd01851
    Location:174410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:697757
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:580641
    PHD_SF; PHD finger superfamily
  2. NM_001281735.1NP_001268664.1  zinc finger FYVE domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001268664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AK098542, AL442663, AW070816, BU740588, BX339655, CK005173, HY248287
    Consensus CDS
    CCDS41969.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000377757, OTTHUMP00000245918, ENST00000394207, OTTHUMT00000413173
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily
  3. NM_021260.3NP_067083.1  zinc finger FYVE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_067083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB046809, BC053520, DB059103, HY248287
    Consensus CDS
    CCDS9811.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000450742, OTTHUMP00000245917, ENST00000556143, OTTHUMT00000413172
    Conserved Domains (3) summary
    cd01851
    Location:174410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:594655
    PHD_SF; PHD finger superfamily
  4. NM_178441.2NP_848535.1  zinc finger FYVE domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_848535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AF311602, AI073571, AW070816, BX339655, CK005173, HY248287
    Consensus CDS
    CCDS41969.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000452232, OTTHUMP00000245919, ENST00000555072, OTTHUMT00000413174
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    72969445..73027212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536839.1XP_011535141.1  

    See identical proteins and their annotated locations for XP_011535141.1

    UniProtKB/Swiss-Prot
    Q9HBF4
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily

RNA

  1. XR_943478.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    73374312..73431997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)