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Ube2k ubiquitin-conjugating enzyme E2K [ Mus musculus (house mouse) ]

Gene ID: 53323, updated on 20-Aug-2016
Official Symbol
Ube2kprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Kprovided by MGI
Primary source
MGI:MGI:1858216
See related
Ensembl:ENSMUSG00000029203 Vega:OTTMUSG00000028413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lig; Hip2; Hypg; HIP-2; E2-25k; AW492011; D5Ertd601e
Orthologs
Location:
5 C3.1; 5 33.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (65537082..65598989)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (65928500..65990228)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene lipoic acid synthetase Neighboring gene UDP-glucose dehydrogenase Neighboring gene small integral membrane protein 14 Neighboring gene predicted gene, 40309 Neighboring gene PDS5 cohesin associated factor A Neighboring gene uncharacterized LOC108169121

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin conjugating enzyme activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ubiquitin-conjugating enzyme E2 K
Names
E2 ubiquitin-conjugating enzyme K
huntingtin interacting protein 2
ubiquitin carrier protein
ubiquitin-conjugating enzyme E2-25 kDa
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
ubiquitin-protein ligase
NP_001297547.1
NP_001297548.1
NP_058066.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310618.1NP_001297547.1  ubiquitin-conjugating enzyme E2 K isoform 2

    See identical proteins and their annotated locations for NP_001297547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK036068, AK139564, AK149463, CF538783
    Consensus CDS
    CCDS80289.1
    UniProtKB/TrEMBL
    A0A0J9YU07, Q6ZWQ6
    Related
    ENSMUSP00000143941, OTTMUSP00000072084, ENSMUST00000201984, OTTMUST00000136625
    Conserved Domains (2) summary
    smart00212
    Location:22103
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    cl21463
    Location:112149
    UBA_like_SF; UBA domain-like superfamily
  2. NM_001310619.1NP_001297548.1  ubiquitin-conjugating enzyme E2 K isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct, shorter N-terminus than isoform 1.
    Source sequence(s)
    AC112263, AC136513
    Conserved Domains (2) summary
    smart00212
    Location:284
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    cl21463
    Location:93130
    UBA_like_SF; UBA domain-like superfamily
  3. NM_016786.4NP_058066.2  ubiquitin-conjugating enzyme E2 K isoform 1

    See identical proteins and their annotated locations for NP_058066.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK036068, AK139564, AK149463
    Consensus CDS
    CCDS39098.1
    UniProtKB/Swiss-Prot
    P61087
    UniProtKB/TrEMBL
    Q6ZWQ6
    Related
    ENSMUSP00000122471, OTTMUSP00000035874, ENSMUST00000142407, OTTMUST00000070400
    Conserved Domains (3) summary
    COG5078
    Location:1153
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:6149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cd14390
    Location:163200
    UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    65537082..65598989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320985.1XP_017176474.1  

    Related
    ENSMUSP00000144366, OTTMUSP00000072087, ENSMUST00000202679, OTTMUST00000136627