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Nucb2 nucleobindin 2 [ Mus musculus (house mouse) ]

Gene ID: 53322, updated on 8-Jul-2014
Official Symbol
Nucb2provided by MGI
Official Full Name
nucleobindin 2provided by MGI
Primary source
MGI:1858179
See related
Ensembl:ENSMUSG00000030659; Vega:OTTMUSG00000043201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nefa; Calnuc; AI607786; Nesfatin-1
See Nucb2 in Epigenomics, MapViewer
Location:
7 F1; 7
Exon count :
16
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (116504353..116540588)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102637815 Neighboring gene phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide Neighboring gene 10 kDa heat shock protein, mitochondrial-like Neighboring gene predicted gene 9197 Neighboring gene voltage-dependent anion channel 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nucleobindin-2
Names
nucleobindin-2
prepronefastin
prepronesfatin
DNA-binding protein NEFA

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130479.2NP_001123951.1  nucleobindin-2 precursor

    See proteins identical to NP_001123951.1

    Status: VALIDATED

    Source sequence(s)
    AC163222, AK152672, AK160442, BF462404, BY142521
    Consensus CDS
    CCDS52372.1
    UniProtKB/Swiss-Prot
    P81117
    UniProtKB/TrEMBL
    Q3TV28
    Related
    ENSMUSP00000032895, OTTMUSP00000063387, ENSMUST00000032895, OTTMUST00000113295
    Conserved Domains (2) summary
    cd00051
    Location:250321
    Blast Score: 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:251321
    Blast Score: 92
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    116504353..116540588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508027.1XP_006508090.1  

    See proteins identical to XP_006508090.1

    Conserved Domains (1) summary
    COG1429
    Location:24196
    Blast Score: 86
    CobN; Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]
  2. XM_006508028.1XP_006508091.1  

    See proteins identical to XP_006508091.1

    Conserved Domains (1) summary
    COG1429
    Location:24196
    Blast Score: 86
    CobN; Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]
  3. XM_006508026.1XP_006508089.1  

    See proteins identical to XP_006508089.1

    Conserved Domains (1) summary
    COG1429
    Location:24196
    Blast Score: 86
    CobN; Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]
  4. XM_006508024.1XP_006508087.1  

    See proteins identical to XP_006508087.1

    UniProtKB/Swiss-Prot
    P81117
    Conserved Domains (2) summary
    cd00051
    Location:250321
    Blast Score: 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:251321
    Blast Score: 92
    EF-hand_7; EF-hand domain pair
  5. XM_006508025.1XP_006508088.1  

    See proteins identical to XP_006508088.1

    UniProtKB/Swiss-Prot
    P81117
    Conserved Domains (2) summary
    cd00051
    Location:250321
    Blast Score: 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:251321
    Blast Score: 92
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_378260.1 RNA Sequence

  2. XR_378261.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    116437740..116475120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016773.3: Suppressed sequence

    Description
    NM_016773.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3' end.

Supplemental Content

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