Nucb2 nucleobindin 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Nucb2provided by MGI
Official Full Name: nucleobindin 2provided by MGI
Primary source: MGI:1858179
See related: Ensembl:ENSMUSG00000030659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nefa; Calnuc; AI607786; Nesfatin-1

Genomic context

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Location :: 7 F1; 7

Sequence :: Chromosome: 7; NC_000073.6 (116504369..116540588)

See Nucb2 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation
Title: Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation.
Gastric mTOR is a gastric energy sensor whose activity is linked to the regulation of gastric nesfatin-1/NUCB2.
Title: mTOR-dependent modulation of gastric nesfatin-1/NUCB2.
NUCB2 may operate directly at the testicular level to link energy homeostasis, puberty onset, and gonadal function
Title: Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis.
Nesfatin-1 is distributed in mouse brain areas involved in the regulation of stress response and visceral functions activated by an acute psychological stressor; nesfatin-1 might play a role in the efferent component of the stress response.
Title: Localization of nesfatin-1 neurons in the mouse brain and functional implication.
nesfatin-1 potentiates glucose-induced insulin secretion by promoting Ca(2+) influx through L-type Ca(2+) channels independently of PKA and PLA(2) in mouse islet beta-cells.
Title: Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet β-cells.
Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals
Title: Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals.
these findings indicate that nesfatin-1 is a novel glucose-dependent insulinotropic peptide and that alterations in endogenous nesfatin-1 in the pancreatic islets could contribute to diabetes and diet-induced obese.
Title: Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.
Data report that nesfatin-1 is a novel depot specific adipokine preferentially produced by sc tissue, with obesity- and food deprivation-regulated expression.
Title: Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity.
nesfatin-1/NUCB2 immunoreactive cells were localized in the central part of the pancreatic islets, the lower third and middle portion of the gastric mucosal gland, and the submucous layer of the duodenum
Title: Expression of nesfatin-1/NUCB2 in rodent digestive system.
Ucn1, CART and nesfatin-1/NUCB2 are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse
Title: Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus.

Submit: New GeneRIF Correction See all (13)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Homology

Homologs of the Nucb2 gene: The Nucb2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleobindin-2

Names: nucleobindin-2; prepronefastin; prepronesfatin; DNA-binding protein NEFA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130479.2 → NP_001123951.1 nucleobindin-2 precursor

Status: VALIDATED

Source sequence(s)

AC163222, AK152672, AK160442, BF462404, BY142521

Consensus CDS

CCDS52372.1

UniProtKB/Swiss-Prot

P81117

UniProtKB/TrEMBL

Q3TV28

Related

ENSMUSP00000032895, ENSMUST00000032895

Conserved Domains (1) summary

pfam13499
Location:251 – 321
Blast Score: 82

EF_hand_5; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

116504369..116540588

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

116437740..116475120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_016773.3: Suppressed sequence

Description

NM_016773.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3' end.

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01065662.1 (2450..5580)	None
genomic	AAHY01065663.1	None
genomic	AAHY01065664.1	None
genomic	AAHY01065665.1	None
genomic	AC163222.4 (142313..178498)	None
genomic	CH466531.1	EDL17108.1	mixed
		EDL17109.1	mixed
		EDL17110.1	mixed
		EDL17111.1	mixed
		EDL17112.1	mixed
mRNA	AI849795.1	None	C57BL/6J
mRNA	AJ222586.1	CAA10858.1	Swiss Webster/NIH
mRNA	AK145934.1	BAE26765.1	C57BL/6J
mRNA	AK152672.1	None	C57BL/6J
mRNA	AK160442.1	BAE35792.1	C57BL/6J
mRNA	AK210501.1	None
mRNA	BC010459.1	AAH10459.1	FVB/N
mRNA	BF462404.1	None	C57BL/6J
mRNA	BY142521.1	None	C57BL/6J