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PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) [ Homo sapiens (human) ]

Gene ID: 5331, updated on 26-Aug-2014
Official Symbol
PLCB3provided by HGNC
Official Full Name
phospholipase C, beta 3 (phosphatidylinositol-specific)provided by HGNC
Primary source
HGNC:9056
See related
Ensembl:ENSG00000149782; HPRD:02577; MIM:600230; Vega:OTTHUMG00000167816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
See PLCB3 in Epigenomics, MapViewer
Location:
11q13
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (64251523..64269452)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64018995..64036924)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 2, 13kDa Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B Neighboring gene uncharacterized LOC101927696 Neighboring gene BCL2-associated agonist of cell death Neighboring gene G protein-coupled receptor 137 Neighboring gene potassium channel, subfamily K, member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Protein Interaction Database

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    Phosphatidylinositol signaling system, organism-specific biosystem
    Phosphatidylinositol signaling system
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  • Presynaptic function of Kainate receptors, organism-specific biosystem (from REACTOME)
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  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
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  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
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    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Salivary secretion, organism-specific biosystem (from KEGG)
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  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal Transduction of S1P Receptor, organism-specific biosystem (from WikiPathways)
    Signal Transduction of S1P Receptor, organism-specific biosystemMetabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystem (from REACTOME)
    Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystemAn array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol (Irvine & Schell 2001, Bunney & Katan 2...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
    Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Thyroid hormone synthesis, conserved biosystem (from KEGG)
    Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • phospholipases, organism-specific biosystem (from BIOCYC)
    phospholipases, organism-specific biosystem
    phospholipases
  • superpathway of inositol phosphate compounds, organism-specific biosystem (from BIOCYC)
    superpathway of inositol phosphate compounds, organism-specific biosystem
    superpathway of inositol phosphate compounds
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
PLC beta 3
PLC-beta-3
phosphoinositide phospholipase C-beta-3
NP_000923.1
NP_001171812.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000932.2NP_000923.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1

    See proteins identical to NP_000923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP001453, BC142681
    Consensus CDS
    CCDS8064.1
    UniProtKB/Swiss-Prot
    Q01970
    Conserved Domains (7) summary
    pfam09279
    Location:225315
    Blast Score: 252
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:728843
    Blast Score: 341
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08625
    Location:316693
    Blast Score: 1364
    PI-PLCc_beta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta3
    cd13361
    Location:22149
    Blast Score: 535
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:10241203
    Blast Score: 593
    PLC-beta_C; PLC-beta C terminal
    pfam15453
    Location:8941047
    Blast Score: 96
    Pilt; Protein incorporated later into Tight Junctions
    cl12013
    Location:10231146
    Blast Score: 93
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001184883.1NP_001171812.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2

    See proteins identical to NP_001171812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame portion of the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AP001453, BC032659
    Consensus CDS
    CCDS53654.1
    UniProtKB/Swiss-Prot
    Q01970
    Conserved Domains (7) summary
    pfam09279
    Location:158248
    Blast Score: 251
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:661776
    Blast Score: 341
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08625
    Location:249626
    Blast Score: 1360
    PI-PLCc_beta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta3
    pfam08703
    Location:9571136
    Blast Score: 585
    PLC-beta_C; PLC-beta C terminal
    pfam15453
    Location:827980
    Blast Score: 95
    Pilt; Protein incorporated later into Tight Junctions
    cl12013
    Location:9561079
    Blast Score: 92
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17171
    Location:3382
    Blast Score: 201
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    64251523..64269452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274052.2XP_005274109.1  

    See proteins identical to XP_005274109.1

    UniProtKB/Swiss-Prot
    Q01970
    Related
    ENSP00000443631, OTTHUMP00000236935, ENST00000540288, OTTHUMT00000396405
    Conserved Domains (7) summary
    pfam09279
    Location:225315
    Blast Score: 252
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:728843
    Blast Score: 341
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08625
    Location:316693
    Blast Score: 1364
    PI-PLCc_beta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta3
    cd13361
    Location:22149
    Blast Score: 535
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:10241203
    Blast Score: 593
    PLC-beta_C; PLC-beta C terminal
    pfam15453
    Location:8941047
    Blast Score: 96
    Pilt; Protein incorporated later into Tight Junctions
    cl12013
    Location:10231146
    Blast Score: 93
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    60321780..60364717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    63901992..63919919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)