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    isdB iron-regulated heme-iron binding protein IsdB [ Staphylococcus aureus subsp. aureus str. Newman ]

    Gene ID: 5330644, updated on 20-Apr-2013
    Gene symbol
    isdB
    Gene description
    iron-regulated heme-iron binding protein IsdB
    Locus tag
    NWMN_1040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Staphylococcus aureus subsp. aureus str. Newman (strain: Newman, sub-species: aureus)
    Lineage
    Bacteria; Firmicutes; Bacillales; Staphylococcus
    Sequence :
    NC_009641.1 (1142080..1144017, complement)

    NC_009641.1Genomic Context describing neighboring genes Neighboring gene phage tail fiber Neighboring gene hypothetical protein Neighboring gene phage holin Neighboring gene phage amidase Neighboring gene iron-regulated heme-iron binding protein IsdA Neighboring gene iron-regulated cell surface protein Neighboring gene hypothetical protein

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme. Spirig T, et al. J Biol Chem, 2013 Jan 11. PMID 23132864.
    2. The iron-regulated surface proteins IsdA, IsdB, and IsdH are not required for heme iron utilization in Staphylococcus aureus. Hurd AF, et al. FEMS Microbiol Lett, 2012 Apr. PMID 22268825.
    3. Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets. Miajlovic H, et al. Microbiology, 2010 Mar. PMID 20007649.
    4. Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB. Pishchany G, et al. Infect Immun, 2009 Jul. PMID 19398548.
    5. Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. Baba T, et al. J Bacteriol, 2008 Jan. PMID 17951380.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Here we demonstrate that each receptor IsdB and IsdH) captures heme using two conserved near iron transporter (NEAT) domains that function synergistically
      Title: Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.
    2. Using a mouse septic arthritis model of The triple IsdA, IsdB and IsdH mutant was found to have no defect in growth under any conditions of iron limitation tested.
      Title: The iron-regulated surface proteins IsdA, IsdB, and IsdH are not required for heme iron utilization in Staphylococcus aureus.
    3. IsdB binds to platelets by a direct interaction with the platelet integrin GPIIb/IIIa.
      Title: Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets.
    4. Virulence studies revealed that IsdB is required for the efficient colonization of the heart.
      Title: Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB.
    Submit: New GeneRIF Correction
    Names
    iron-regulated heme-iron binding protein IsdB

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009641.1

      Range
      1142080..1144017, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001332074.1 iron-regulated heme-iron binding protein IsdB [Staphylococcus aureus subsp. aureus str. Newman]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A6QG30
      Conserved Domains (5) summary
      cd06920
      Location:345 – 455
      Blast Score: 188
      NEAT; NEAr Transport domain, a component of cell surface proteins
      pfam04650
      Location:1 – 32
      Blast Score: 107
      YSIRK_signal; YSIRK type signal peptide
      TIGR03657
      Location:1 – 645
      Blast Score: 2039
      IsdB; heme uptake protein IsdB
      smart00725
      Location:145 – 268
      Blast Score: 260
      NEAT; NEAr Transporter domain
      pfam00746
      Location:603 – 644
      Blast Score: 92
      Gram_pos_anchor; Gram positive anchor
    Nucleotide Protein
    Heading Accession and Version
    genomic AP009351.1 BAF67312.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QG30.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
        BioProjects related to a gene
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • Protein Clusters
        Related Protein Clusters
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      Links to other resources

      General information

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