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PLAUR plasminogen activator, urokinase receptor [ Homo sapiens (human) ]

Gene ID: 5329, updated on 26-Aug-2014
Official Symbol
PLAURprovided by HGNC
Official Full Name
plasminogen activator, urokinase receptorprovided by HGNC
Primary source
HGNC:9053
See related
Ensembl:ENSG00000011422; HPRD:01421; MIM:173391; Vega:OTTHUMG00000182778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD87; UPAR; URKR; U-PAR
Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
See PLAUR in Epigenomics, MapViewer
Location:
19q13
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (43646095..43670346, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44150247..44174498, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene cell adhesion molecule 4 Neighboring gene immunity-related GTPase family, cinema Neighboring gene SMG9 nonsense mediated mRNA decay factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
capsid gag A peptide (Ch7) derived from HIV-1 Capsid (amino acids 232-238) has been shown to have immunosuppressive effects through a possible interaction with the Plasminogen Receptor, indicating a role for Capsid in the immunosuppressive effects of HIV-1 PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
urokinase plasminogen activator receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
C-terminal protein lipidation TAS
Traceable Author Statement
more info
 
attachment of GPI anchor to protein TAS
Traceable Author Statement
more info
 
blood coagulation NAS
Non-traceable Author Statement
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular component movement NAS
Non-traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
fibrinolysis TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
urokinase plasminogen activator signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
extrinsic component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
urokinase plasminogen activator surface receptor
Names
urokinase plasminogen activator surface receptor
monocyte activation antigen Mo3
u-plasminogen activator receptor form 2
urokinase-type plasminogen activator (uPA) receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032898.1 

    Range
    5001..29252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005376.2NP_001005376.1  urokinase plasminogen activator surface receptor isoform 2 precursor

    See proteins identical to NP_001005376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. Variant 2 encodes the shortest isoform (2), also called suPLAUR, which is the soluble form of this protein. Isoform 2 lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 1.
    Source sequence(s)
    AI801128, AI912302, CA495321, X74039
    Consensus CDS
    CCDS33041.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000342049, OTTHUMP00000270126, ENST00000339082, OTTHUMT00000463568
    Conserved Domains (3) summary
    cd00117
    Location:115201
    Blast Score: 140
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    pfam00021
    Location:2599
    Blast Score: 108
    UPAR_LY6; u-PAR/Ly-6 domain
    cl10471
    Location:215252
    Blast Score: 91
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_001005377.2NP_001005377.1  urokinase plasminogen activator surface receptor isoform 3 precursor

    See proteins identical to NP_001005377.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one exon in the coding region and encodes an isoleucine rather than a valine following the splice site, compared to variant 1. Variant 3 encodes isoform 3 which is longer and lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 2.
    Source sequence(s)
    CA495321, CD370232, U08839
    Consensus CDS
    CCDS33042.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000221264, OTTHUMP00000270130, ENST00000221264, OTTHUMT00000463572
    Conserved Domains (1) summary
    cd00117
    Location:170251
    Blast Score: 176
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_001301037.1NP_001287966.1  urokinase plasminogen activator surface receptor isoform 4 precursor

    See proteins identical to NP_001287966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK290774, BY996586, CA495321, CF126152
    Consensus CDS
    CCDS74386.1
    Conserved Domains (2) summary
    cd00117
    Location:115201
    Blast Score: 148
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:193245
    Blast Score: 83
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. NM_002659.3NP_002650.1  urokinase plasminogen activator surface receptor isoform 1 precursor

    See proteins identical to NP_002650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1) which contains three LU (Ly-6 antigen/uPA receptor-like) domains.
    Source sequence(s)
    BC002788, CA495321, CD370232
    Consensus CDS
    CCDS12628.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000339328, OTTHUMP00000270129, ENST00000340093, OTTHUMT00000463571
    Conserved Domains (1) summary
    cd00117
    Location:215296
    Blast Score: 175
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    43646095..43670346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258989.1XP_005259046.1  

    UniProtKB/TrEMBL
    M0R1I2
    Related
    ENSP00000471881, OTTHUMP00000270128, ENST00000601723, OTTHUMT00000463570
    Conserved Domains (2) summary
    cd00117
    Location:115201
    Blast Score: 148
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:193245
    Blast Score: 83
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. XM_006723241.1XP_006723304.1  

    Conserved Domains (2) summary
    cd00117
    Location:190271
    Blast Score: 176
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:674
    Blast Score: 103
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. XM_005258988.2XP_005259045.1  

    Conserved Domains (1) summary
    cd00117
    Location:210291
    Blast Score: 177
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. XM_005258990.2XP_005259047.1  

    See proteins identical to XP_005259047.1

    Conserved Domains (2) summary
    cd00117
    Location:115201
    Blast Score: 140
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    pfam00021
    Location:2599
    Blast Score: 108
    UPAR_LY6; u-PAR/Ly-6 domain

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    40580832..40605572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    44151900..44176634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)