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PLAGL1 PLAG1 like zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 5325, updated on 7-Feb-2016
Official Symbol
PLAGL1provided by HGNC
Official Full Name
PLAG1 like zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:9046
See related
Ensembl:ENSG00000118495; HPRD:16010; MIM:603044; Vega:OTTHUMG00000015738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAC; LOT1; ZAC1
Summary
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Orthologs
See PLAGL1 in Epigenomics, MapViewer
Location:
6q24-q25
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (143940300..144064599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144261437..144385736, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene hydatidiform mole associated and imprinted (non-protein coding) Neighboring gene FK506 binding protein 7 pseudogene Neighboring gene uncharacterized LOC105378036 Neighboring gene splicing factor 3b subunit 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of pleiomorphic adenoma gene-like 1 (PLAGL1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126275, MGC126276, DKFZp781P1017

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
zinc finger protein PLAGL1
Names
PLAG-like 1
lost on transformation 1
pleiomorphic adenoma gene-like 1
tumor suppressor ZAC

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009384.1 RefSeqGene

    Range
    5000..129299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080951.2NP_001074420.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA675185, DA991276, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001080952.2NP_001074421.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as P1G) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, EF100448, EF100452, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001080953.2NP_001074422.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as P1E) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, EF100448, EF100450, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001080954.2NP_001074423.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as P1D) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA595200, EF100448, EF100449, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001080955.2NP_001074424.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001074424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as P2C) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA675185, DA991276, EF100440
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001080956.2NP_001074425.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001074425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA426770, U72621
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001289037.1NP_001275966.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as P2B) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001289038.1NP_001275967.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as P2D) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100441
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000392418, ENST00000437412
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001289039.1NP_001275968.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as P2H) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100443
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_001289040.1NP_001275969.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14, also known as P2I) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439, EF100444
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_001289041.1NP_001275970.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21, also known as P1F) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA717476, DA806571
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001289042.1NP_001275971.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as P2A) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100438
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001289043.1NP_001275972.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as P2E) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100442
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000400929, ENST00000444202
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001289044.1NP_001275973.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as P2J) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100445
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_001289045.1NP_001275974.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AK096331, AW136077, DA385311, DA806571
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000486355, OTTHUMP00000278490, ENST00000625622, OTTHUMT00000481674
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_001289046.1NP_001275975.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000346810, OTTHUMP00000017346, ENST00000354765, OTTHUMT00000042540
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_001289047.1NP_001275976.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18, also known as P1A) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100446
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000400060, ENST00000416623
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  18. NM_001289048.1NP_001275977.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19, also known as P1B) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  19. NM_001289049.1NP_001275978.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20, also known as P1C) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  20. NM_001317156.1NP_001304085.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AL049844, AL109755
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  21. NM_001317157.1NP_001304086.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ006354, AJ311395, EF100447
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  22. NM_001317158.1NP_001304087.1  zinc finger protein PLAGL1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AL049844, AL109755, U81992
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  23. NM_001317159.1NP_001304088.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DB177852, EF100448
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  24. NM_001317160.1NP_001304089.1  zinc finger protein PLAGL1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA549753, U72621
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
  25. NM_001317161.1NP_001304090.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, AL109755, DA025970, U72621
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  26. NM_001317162.1NP_001304091.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA370204, U72621
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  27. NM_006718.4NP_006709.2  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_006709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates from the P1 promoter and encodes the longer isoform (2). Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA391124, DA549753, EF100447, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    143940300..144064599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    144524320..144648633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002656.3: Suppressed sequence

    Description
    NM_002656.3: This RefSeq was removed because currently there is insufficient support for the transcript.