Display Settings:

Format

Send to:

Choose Destination

PLAGL1 pleiomorphic adenoma gene-like 1 [ Homo sapiens (human) ]

Gene ID: 5325, updated on 21-Oct-2014
Official Symbol
PLAGL1provided by HGNC
Official Full Name
pleiomorphic adenoma gene-like 1provided by HGNC
Primary source
HGNC:HGNC:9046
Locus tag
RP3-468K18.1
See related
Ensembl:ENSG00000118495; HPRD:16010; MIM:603044; Vega:OTTHUMG00000015738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAC; LOT1; ZAC1
Summary
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
See PLAGL1 in Epigenomics, MapViewer
Location:
6q24-q25
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (143940300..144064599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144261437..144385736, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene hydatidiform mole associated and imprinted (non-protein coding) Neighboring gene FK506 binding protein 7 pseudogene Neighboring gene splicing factor 3b, subunit 5, 10kDa Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of pleiomorphic adenoma gene-like 1 (PLAGL1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126275, MGC126276, DKFZp781P1017

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
zinc finger protein PLAGL1
Names
zinc finger protein PLAGL1
LOT-1
PLAG-like 1
tumor supressor ZAC
tumor suppressor ZAC
lost on transformation 1
pleiomorphic adenoma-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009384.1 

    Range
    5000..129299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080951.1NP_001074420.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001074420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA991276, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  2. NM_001080952.1NP_001074421.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001074421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA446007, DA549753, EF100448, EF100452
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  3. NM_001080953.1NP_001074422.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001074422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA446007, DA549753, EF100448, EF100450
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  4. NM_001080954.1NP_001074423.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001074423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA446007, DA549753, DA595200, EF100448, EF100449
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  5. NM_001080955.1NP_001074424.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001074424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA991276, EF100440
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  6. NM_001080956.1NP_001074425.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001074425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA426770, DA446007, DA549753
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  7. NM_001289037.1NP_001275966.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001275966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  8. NM_001289038.1NP_001275967.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001275967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100441
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000392418, ENST00000437412
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  9. NM_001289039.1NP_001275968.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001275968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100443
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  10. NM_001289040.1NP_001275969.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001275969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439, EF100444
    Consensus CDS
    CCDS5203.1
    UniProtKB/TrEMBL
    A1YLA2
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  11. NM_001289041.1NP_001275970.1  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_001275970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 1. Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA717476, DA806571
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  12. NM_001289042.1NP_001275971.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100438
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  13. NM_001289043.1NP_001275972.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100442
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000400929, ENST00000444202
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  14. NM_001289044.1NP_001275973.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100445
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  15. NM_001289045.1NP_001275974.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AK096331, AW136077, DA385311, DA806571
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  16. NM_001289046.1NP_001275975.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000346810, OTTHUMP00000017346, ENST00000354765, OTTHUMT00000042540
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  17. NM_001289047.1NP_001275976.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100446
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000400060, ENST00000416623
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  18. NM_001289048.1NP_001275977.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  19. NM_001289049.1NP_001275978.1  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_001275978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  20. NM_002656.3NP_002647.2  zinc finger protein PLAGL1 isoform 1

    See proteins identical to NP_002647.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 7, 8, 9 11, 13, 14 and 21 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA391124, DA446007, DA549753
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
    cl17238
    Location:28155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  21. NM_006718.3NP_006709.2  zinc finger protein PLAGL1 isoform 2

    See proteins identical to NP_006709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the CDS compared to variant 1. The resulting isoform (2) is longer and has an extended N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19 and 20 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA391124, DA446007, DA549753, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/TrEMBL
    A1YLA1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (2) summary
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
    cl17238
    Location:80207
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    143940300..144064599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    141825091..141949489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    144524320..144648633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)