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PLA2G5 phospholipase A2, group V [ Homo sapiens (human) ]

Gene ID: 5322, updated on 22-Mar-2015
Official Symbol
PLA2G5provided by HGNC
Official Full Name
phospholipase A2, group Vprovided by HGNC
Primary source
HGNC:HGNC:9038
See related
Ensembl:ENSG00000127472; HPRD:03117; MIM:601192; Vega:OTTHUMG00000002698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRFB; GV-PLA2; PLA2-10; hVPLA(2)
Summary
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
See PLA2G5 in MapViewer
Location:
1p36-p34
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (20028339..20091901)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20386157..20418394)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IIE Neighboring gene phospholipase A2, group IIA (platelets, synovial fluid) Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2, group IID Neighboring gene phospholipase A2, group IIF

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC46205, DKFZp686C2294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
leukotriene biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
platelet activating factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
calcium-dependent phospholipase A2
Names
calcium-dependent phospholipase A2
Ca2+-dependent phospholipase A2
phosphatidylcholine 2-acylhydrolase 5
NP_000920.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032045.1 RefSeqGene

    Range
    5001..26694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000929.2NP_000920.1  calcium-dependent phospholipase A2 precursor

    See proteins identical to NP_000920.1

    Status: REVIEWED

    Source sequence(s)
    AL158172, AV709457, BC036792, BM684907, BM705479
    Consensus CDS
    CCDS202.1
    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    20028339..20091901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541589.1XP_011539891.1  

    See proteins identical to XP_011539891.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. XM_011541587.1XP_011539889.1  

    See proteins identical to XP_011539889.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. XM_011541588.1XP_011539890.1  

    See proteins identical to XP_011539890.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  4. XM_011541590.1XP_011539892.1  

    See proteins identical to XP_011539892.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  5. XM_011541591.1XP_011539893.1  

    See proteins identical to XP_011539893.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  6. XM_011541592.1XP_011539894.1  

    See proteins identical to XP_011539894.1

    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  7. XM_005245891.3XP_005245948.1  

    See proteins identical to XP_005245948.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  8. XM_005245892.3XP_005245949.1  

    See proteins identical to XP_005245949.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  9. XM_011541586.1XP_011539888.1  

    See proteins identical to XP_011539888.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  10. XM_005245893.3XP_005245950.1  

    See proteins identical to XP_005245950.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  11. XM_011541584.1XP_011539886.1  

    See proteins identical to XP_011539886.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  12. XM_011541585.1XP_011539887.1  

    See proteins identical to XP_011539887.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  13. XM_006710696.2XP_006710759.1  

    See proteins identical to XP_006710759.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    20506410..20528103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)