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PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) [ Homo sapiens (human) ]

Gene ID: 5320, updated on 26-Aug-2014
Official Symbol
PLA2G2Aprovided by HGNC
Official Full Name
phospholipase A2, group IIA (platelets, synovial fluid)provided by HGNC
Primary source
HGNC:9031
See related
Ensembl:ENSG00000188257; HPRD:01397; MIM:172411; Vega:OTTHUMG00000002699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
See PLA2G2A in Epigenomics, MapViewer
Location:
1p35
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (19975431..19980439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20301924..20306932, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 3 Neighboring gene phospholipase A2, group IIE Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2, group V

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase A2 activity TAS
Traceable Author Statement
more info
PubMed 
phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phospholipase A2, membrane associated
Names
phospholipase A2, membrane associated
NPS-PLA2
GIIC sPLA2
group IIA phospholipase A2
phosphatidylcholine 2-acylhydrolase 2A
non-pancreatic secretory phospholipase A2
NP_000291.1
NP_001155199.1
NP_001155200.1
NP_001155201.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012928.1 

    Range
    5001..10009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000300.3NP_000291.1  phospholipase A2, membrane associated precursor

    See proteins identical to NP_000291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant and longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BU626291, BX641714
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    Related
    ENSP00000364252, OTTHUMP00000002786, ENST00000375111, OTTHUMT00000007675
    Conserved Domains (1) summary
    cd00125
    Location:21137
    Blast Score: 397
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. NM_001161727.1NP_001155199.1  phospholipase A2, membrane associated precursor

    See proteins identical to NP_001155199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BU626291, BX641714, CB132375
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    Conserved Domains (1) summary
    cd00125
    Location:21137
    Blast Score: 397
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. NM_001161728.1NP_001155200.1  phospholipase A2, membrane associated precursor

    See proteins identical to NP_001155200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BU626291, BX641714
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    Conserved Domains (1) summary
    cd00125
    Location:21137
    Blast Score: 397
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  4. NM_001161729.1NP_001155201.1  phospholipase A2, membrane associated precursor

    See proteins identical to NP_001155201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BM708748, BU626291
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    Related
    ENSP00000383364, ENST00000400520
    Conserved Domains (1) summary
    cd00125
    Location:21137
    Blast Score: 397
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    19975431..19980439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    18547710..18552716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    20411642..20416650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)