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    PI4KB phosphatidylinositol 4-kinase, catalytic, beta [ Homo sapiens ]

    Gene ID: 5298, updated on 11-May-2012
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    Summary

    Official Symbol
    PI4KBprovided by HGNC
    Official Full Name
    phosphatidylinositol 4-kinase, catalytic, betaprovided by HGNC
    Primary source
    HGNC:8984
    Locus tag
    RP11-126K1.4
    See related
    Ensembl:ENSG00000143393; HPRD:11805; MIM:602758; Vega:OTTHUMG00000012348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIK; PI4K92; PIK4CB; PI4KBETA; PI4K-BETA; PI4KIIIBETA; FLJ30129; DKFZp686O1820
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    Genomic context

    Location :
    1q21
    Sequence :
    Chromosome: 1; NC_000001.10 (151264273..151300191, complement)
    See PI4KB in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Neighboring gene uncharacterized LOC100507670 Neighboring gene zinc finger protein 687 Neighboring gene uncharacterized LOC100505481 Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene selenium binding protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Phosphatidylinositol 4-kinase IIIβ is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry. Yang N, et al. J Biol Chem, 2012 Mar 9. PMID 22253445.
    2. ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites. Sasaki J, et al. EMBO J, 2011 Nov 29. PMID 22124328.
    3. The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis. Pinke DE, et al. Exp Cell Res, 2011 Oct 15. PMID 21851817.
    4. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. Zakharian E, et al. FASEB J, 2011 Nov. PMID 21810903.
    5. Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90. Jung G, et al. J Biol Chem, 2011 Apr 8. PMID 21330372.

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Phosphatidylinositol 4-kinase IIIbeta is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry.
      Title: Phosphatidylinositol 4-kinase IIIβ is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry.
    2. results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication
      Title: ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.
    3. Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks
      Title: Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂.
    4. The PI4KIIIbeta likely plays an important role in mammary neoplasia and acinar development.
      Title: The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.
    5. Study identify the molecular chaperone Hsp90 as a binding partner of PI4KIIbeta, but not of PI4KIIalpha.
      Title: Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90.
    6. Knockdown of PI4KIIalpha does not inhibit EGF-stimulated Akt phosphorylation.
      Title: Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis.
    7. our library screening completed data on the clathrin-mediated endocytosis-dependant entry route of HCV and identified 2 kinases, PI4KIIIalpha and beta, as relevant potential therapeutic targets.
      Title: Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.
    8. genetic or pharmacological modulation of PI4KA and PI4KB inhibits multiple genotypes of HCV
      Title: Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
    10. Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling.
      Title: Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
    Submit: New GeneRIF Correction See all (16)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UBF8 P62166 NCS1    HPRD  PubMed  
    Q9UBF8 P31946 YWHAB    HPRD  PubMed  
    Q9UBF8 P61981 YWHAG    HPRD  PubMed  
    Q9UBF8 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:111316 BioGRID:123873 KBTBD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111316 BioGRID:116985 NCS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111316 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111316 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111316 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111316 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase beta
    Names
    phosphatidylinositol 4-kinase beta
    PtdIns 4-kinase beta
    type III phosphatidylinositol 4-kinase beta
    phosphatidylinositol 4-kinase, wortmannin-sensitive
    NP_001185702.1
    NP_001185703.1
    NP_001185704.1
    NP_002642.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198773.1 → NP_001185702.1  phosphatidylinositol 4-kinase beta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, resulting in a downstream AUG start codon, and also lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB005910, AK311292, AL391069, U81802
      Consensus CDS
      CCDS55638.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357866, OTTHUMP00000014285, ENST00000368872, OTTHUMT00000034403
      Conserved Domains (2) summary
      cd05168
      Location:512 – 801
      Blast Score: 1305
      PI4Kc_III_beta; Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      smart00146
      Location:546 – 751
      Blast Score: 568
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain

    2. NM_001198774.1 → NP_001185703.1  phosphatidylinositol 4-kinase beta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two separated exons in the 5' region, as compared to variant 2. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AB005910, AL391069, BC040300
      Consensus CDS
      CCDS55638.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357868, OTTHUMP00000014283, ENST00000368874, OTTHUMT00000034401
      Conserved Domains (2) summary
      cd05168
      Location:512 – 801
      Blast Score: 1305
      PI4Kc_III_beta; Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      smart00146
      Location:546 – 751
      Blast Score: 568
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain

    3. NM_001198775.1 → NP_001185704.1  phosphatidylinositol 4-kinase beta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three consecutive exons in the 5' region, as compared to variant 1. The resulting in isoform (3) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK294606, AL391069, BC000029, DC350175, DC365634
      Consensus CDS
      CCDS55637.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000433149, OTTHUMP00000230728, ENST00000529142, OTTHUMT00000316335
      Conserved Domains (2) summary
      cd05168
      Location:195 – 484
      Blast Score: 1290
      PI4Kc_III_beta; Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      smart00146
      Location:229 – 434
      Blast Score: 560
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain

    4. NM_002651.2 → NP_002642.1  phosphatidylinositol 4-kinase beta isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB005910, AK311292, AL391069
      Consensus CDS
      CCDS993.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357869, OTTHUMP00000014284, ENST00000368875, OTTHUMT00000034402
      Conserved Domains (2) summary
      cd05168
      Location:539 – 828
      Blast Score: 1304
      PI4Kc_III_beta; Phosphoinositide 4-kinase (PI4K), Type III, beta isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      smart00146
      Location:573 – 778
      Blast Score: 569
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      151264273..151300191, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      122642216..122678133, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL391069.11 CAH70324.1
      CAH70325.1
      CAH70326.1
      CAO72153.1
      CAO72154.1
      CAX15209.1
    genomic CH471121.2 EAW53449.1
      EAW53450.1
    mRNA AB005910.1 BAA21661.1
    mRNA AJ011121.1 CAA09495.1
    mRNA AK054691.1 None
    mRNA AK294606.1 BAG57793.1
    mRNA AK311292.1 None
    mRNA AL832188.1 None
    mRNA BC000029.2 AAH00029.1
    mRNA BC040300.1 AAH40300.1
    mRNA DC350175.1 None
    mRNA DC365634.1 None
    mRNA U81802.1 AAC51156.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UBF8.1 GenPept UniProtKB/Swiss-Prot:Q9UBF8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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