E2f7 E2F transcription factor 7 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: E2f7provided by MGI
Official Full Name: E2F transcription factor 7provided by MGI
Primary source: MGI:1289147
See related: Ensembl:ENSMUSG00000020185; Vega:OTTMUSG00000037938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D10Ertd739e; A630014C11Rik

Genomic context

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Location :: 10 D1; 10 57.74 cM

Sequence :: Chromosome: 10; NC_000076.6 (110745465..110787384)

See E2f7 in Epigenomics, MapViewer

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 pathways.
Title: The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.
Results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development.
Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
E2F7, a novel E2F family member, can block the E2F-dependent activation of a subset of E2F target genes as well as mitigate cellular proliferation of mouse embryo fibroblasts
Title: Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (1) 1 citation

General gene information

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Markers

D10Ertd739e (e-PCR), detects polymorphism
- UniSTS:167035

Homology

Homologs of the E2f7 gene: The E2f7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and A.thaliana.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
core promoter binding	IDA Inferred from Direct Assay more info
core promoter binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription corepressor activity	IDA Inferred from Direct Assay more info
transcription corepressor activity	IMP Inferred from Mutant Phenotype more info

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
cell cycle	IEA Inferred from Electronic Annotation more info
chorionic trophoblast cell differentiation	IMP Inferred from Mutant Phenotype more info
hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info
negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
negative regulation of transcription involved in G1/S phase of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
placenta development	IMP Inferred from Mutant Phenotype more info
positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info
sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor E2F7

Names: transcription factor E2F7; E2F-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178609.4 → NP_848724.2 transcription factor E2F7

Status: VALIDATED

Source sequence(s)

AC147563, AK051521, AK143686

Consensus CDS

CCDS36055.1

UniProtKB/Swiss-Prot

Q6S7F2

UniProtKB/TrEMBL

Q8BQ55

Related

ENSMUSP00000073453, OTTMUSP00000054858, ENSMUST00000073781, OTTMUST00000097803

Conserved Domains (1) summary

pfam02319
Location:143 – 212
Blast Score: 254

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38.p1 C57BL/6J

Range

110745465..110787384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

112679553..112721244

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01088817.1 (101..33540)	None
genomic	AAHY01088818.1	None
genomic	AC147563.4 (81849..123766)	None
genomic	CH466539.1	EDL21712.1	mixed
		EDL21713.1	mixed
		EDL21714.1	mixed
		EDL21715.1	mixed
mRNA	AK031078.1	BAC27243.1	C57BL/6J
mRNA	AK041481.1	BAC30958.1	C57BL/6J
mRNA	AK045040.1	BAC32193.1	C57BL/6J
mRNA	AK051521.1	BAC34662.1	C57BL/6J
mRNA	AK143686.1	BAE25497.1	C57BL/6J
mRNA	AY463359.1	AAR26542.1	C57BL/6J
mRNA	BC055775.1	None	C57BL/6
mRNA	BC145429.1	AAI45430.1
mRNA	BC150772.1	AAI50773.1