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    PGK2 phosphoglycerate kinase 2 [ Homo sapiens ]

    Gene ID: 5232, updated on 11-May-2012

    Summary

    Official Symbol
    PGK2provided by HGNC
    Official Full Name
    phosphoglycerate kinase 2provided by HGNC
    Primary source
    HGNC:8898
    See related
    Ensembl:ENSG00000170950; HPRD:01393; MIM:172270; Vega:OTTHUMG00000014824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGKB; PGKPS; dJ417L20.2
    Summary
    This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

    Genomic context

    Location :
    6p12.3
    Sequence :
    Chromosome: 6; NC_000006.11 (49753364..49755053, complement)
    See PGK2 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505966 Neighboring gene cysteine-rich secretory protein 2 Neighboring gene cysteine-rich secretory protein 3 Neighboring gene cysteine-rich secretory protein 1 Neighboring gene defensin, beta 133

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:111253 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoglycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphoglycerate kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glycolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol NAS
    Non-traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    phosphoglycerate kinase 2
    Names
    phosphoglycerate kinase 2
    phosphoglycerate kinase, testis specific
    phosphoglycerate kinase autosomal pseudogene
    NP_620061.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138733.4NP_620061.2  phosphoglycerate kinase 2

      Status: REVIEWED

      Source sequence(s)
      BC038843, DB043284
      Consensus CDS
      CCDS4930.1
      UniProtKB/Swiss-Prot
      P07205
      Related
      ENSP00000305995, OTTHUMP00000016591, ENST00000304801, OTTHUMT00000040872
      Conserved Domains (2) summary
      cd00318
      Location:14416
      Blast Score: 1481
      Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
      pfam00162
      Location:14406
      Blast Score: 1505
      PGK; Phosphoglycerate kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      49753364..49755053, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      49483695..49485384, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121974.16 CAC19655.1
    genomic HC007210.1 CBH19410.1
    genomic HC044715.1 CBH30687.1
    genomic K03019.1 None
    genomic X05246.1 CAA28872.1
    mRNA AK312770.1 BAG35635.1
    mRNA BC038843.1 AAH38843.1
    mRNA DB043284.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07205.3 GenPept UniProtKB/Swiss-Prot:P07205

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