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    PGA5 pepsinogen 5, group I (pepsinogen A) [ Homo sapiens (human) ]

    Gene ID: 5222, updated on 26-Feb-2013
    Official Symbol
    PGA5provided by HGNC
    Official Full Name
    pepsinogen 5, group I (pepsinogen A)provided by HGNC
    Primary source
    HGNC:8887
    See related
    Ensembl:ENSG00000256713; HPRD:01356; MIM:169730; Vega:OTTHUMG00000168075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGA3; PGA4
    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (61008644..61018929)
    See PGA5 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene pepsinogen 3, group I (pepsinogen A) Neighboring gene pepsinogen 4, group I (pepsinogen A) Neighboring gene von Willebrand factor C and EGF domains Neighboring gene damage-specific DNA binding protein 1, 127kDa Neighboring gene dihydroxyacetone kinase 2 homolog (S. cerevisiae)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    4. Helicobacter pylori genotypes influence serum pepsinogen C levels. Plebani M, et al. Helicobacter, 1997 Dec. PMID 9421118.
    5. The renal handling of pepsinogen A isozymogens in man. Zwiers A, et al. Clin Nephrol, 1994 Mar. PMID 8187358.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    pepsin A-5
    Names
    pepsin A-5
    pepsin A
    pepsinogen-5
    pepsinogen A5
    NP_055039.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014224.2 → NP_055039.1  pepsin A-5 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AP003037
      Consensus CDS
      CCDS8001.1
      UniProtKB/Swiss-Prot
      P0DJD9
      Related
      ENSP00000309542, OTTHUMP00000237822, ENST00000312403, OTTHUMT00000397972
      Conserved Domains (3) summary
      pfam07966
      Location:17 – 45
      Blast Score: 141
      A1_Propeptide; A1 Propeptide
      cd05478
      Location:66 – 386
      Blast Score: 1579
      pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals.
      pfam00026
      Location:75 – 387
      Blast Score: 1190
      Asp; Eukaryotic aspartyl protease

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      61008644..61018929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      57314914..57346848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      60910438..60939599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01003192.1 (24798..25389) None
    genomic ABBA01003193.1 None
    genomic ABBA01003194.1 None
    genomic ABBA01003195.1 None
    genomic ABBA01003196.1 None
    genomic AMYH01003671.1 (13396..18854) None
    genomic AMYH01003672.1 None
    genomic AMYH01003673.1 None
    genomic AMYH01003674.1 None
    genomic AMYH01003675.1 None
    genomic AMYH01003676.1 None
    genomic AMYH01003677.1 None
    genomic AP003037.2 (21157..31442) None
    genomic CH471076.1 EAW73928.1
    genomic J00287.1 AAA98529.1
    genomic M26032.1 AAA60061.1
    genomic M27596.1 AAA36432.1
    genomic M27598.1 AAA36431.1
    mRNA BC029055.1 AAH29055.1
    mRNA BC146999.1 AAI47000.1
    mRNA BC171889.1 AAI71889.1
    mRNA BC171897.1 AAI71897.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DJD9.1 GenPept UniProtKB/Swiss-Prot:P0DJD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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