Pbk PDZ binding kinase [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Pbkprovided by MGI
Official Full Name: PDZ binding kinaseprovided by MGI
Primary source: MGI:1289156
See related: Ensembl:ENSMUSG00000022033; Vega:OTTMUSG00000027681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TOPK; AW538537; D14Ertd732e; 2810434B10Rik

Genomic context

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Location :: 14 D1; 14 34.36 cM

Sequence :: Chromosome: 14; NC_000080.6 (65805911..65817822)

See Pbk in Epigenomics, MapViewer

Chromosome 14 - NC_000080.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.
Title: T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
Title: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Title: Expression and phosphorylation of TOPK during spermatogenesis.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:206338	BioGRID:110264	SMAD4		BioGRID	PubMed	Affinity Capture-Luminescence

General gene information

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Markers

AW538537 (e-PCR)
- UniSTS:180682

D14Ertd732e (e-PCR), detects polymorphism
- UniSTS:167148

Homology

Homologs of the Pbk gene: The Pbk gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and fruit fly.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: lymphokine-activated killer T-cell-originated protein kinase

Names: lymphokine-activated killer T-cell-originated protein kinase; PDZ-binding kinase; MAPKK-like protein kinase; T-LAK cell-originated protein kinase

NP_075698.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023209.2 → NP_075698.1 lymphokine-activated killer T-cell-originated protein kinase

Status: PROVISIONAL

Source sequence(s)

AB041882

Consensus CDS

CCDS27215.1

UniProtKB/Swiss-Prot

Q9JJ78

Related

ENSMUSP00000022612, OTTMUSP00000034645, ENSMUST00000022612, OTTMUST00000068488

Conserved Domains (2) summary

cd00180
Location:37 – 242
Blast Score: 363

PKc; Catalytic domain of Protein Kinases

pfam00069
Location:33 – 315
Blast Score: 367

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000080.6 Reference GRCm38.p1 C57BL/6J

Range

65805911..65817822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000036.1 Alternate Mm_Celera

Range

63558969..63570871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01114650.1 (22142..34044)	None
genomic	AC125058.4 (109750..121661)	None
genomic	CH466535.2	EDL36015.1	mixed
		EDL36016.1	mixed
mRNA	AB041882.1	BAA99578.1
mRNA	AK003838.1	BAB23029.1	C57BL/6J
mRNA	AK076121.1	BAC36199.1	C57BL/6J
mRNA	AK184190.1	None
mRNA	AK217474.1	None
mRNA	BC006754.1	AAH06754.1	FVB/N
mRNA	BC020099.1	AAH20099.1	FVB/N