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CDK2 cyclin dependent kinase 2 [ Bos taurus (cattle) ]

Gene ID: 519217, updated on 5-Mar-2024

Summary

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Official Symbol
CDK2provided by VGNC
Official Full Name
cyclin dependent kinase 2provided by VGNC
Primary source
VGNC:VGNC:27123
See related
BGD:BT19670; Ensembl:ENSBTAG00000004021
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (57338911..57344476, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345301 Neighboring gene RAB5B, member RAS oncogene family Neighboring gene premelanosome protein Neighboring gene diacylglycerol kinase alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proliferative potential of endometrial stromal cells, and endometrial and placental expression of cyclin in the bovine. Yamauchi N, et al. J Reprod Dev, 2003 Dec. PMID 14967908
  2. Comparative organization of cattle chromosome 5 revealed by comparative mapping by annotation and sequence similarity and radiation hybrid mapping. Ozawa A, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10737760, Free PMC Article
  3. Identification of DNA replication and cell cycle proteins that interact with PCNA. Loor G, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396813, Free PMC Article
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 2
Names
cell division protein kinase 2
NP_001014934.1
XP_010803477.1
XP_059742403.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014934.1 → NP_001014934.1  cyclin-dependent kinase 2

    See identical proteins and their annotated locations for NP_001014934.1

    Status: PROVISIONAL

    Source sequence(s)
    BT020790
    UniProtKB/Swiss-Prot
    A6QQX1, Q5E9Y0
    Related
    ENSBTAP00000005252.2, ENSBTAT00000005252.4
    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    57338911..57344476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010805175.4 → XP_010803477.1  cyclin-dependent kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_010803477.1

    Related
    ENSBTAP00000085754.1, ENSBTAT00000105270.1
    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_059886420.1 → XP_059742403.1  cyclin-dependent kinase 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5E9Y0.1 GenPept UniProtKB/Swiss-Prot:Q5E9Y0

Gene LinkOut

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