PHAX phosphorylated adaptor for RNA export [Homo sapiens] - Gene

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Summary

Official Symbol: PHAXprovided by HGNC
Official Full Name: phosphorylated adaptor for RNA exportprovided by HGNC
Primary source: HGNC:10241
See related: Ensembl:ENSG00000164902; HPRD:15122; MIM:604924; Vega:OTTHUMG00000163273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNUXA; FLJ13193

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Genomic context

Location :: 5q23.2

Sequence :: Chromosome: 5; NC_000005.9 (125936607..125962944)

See PHAX in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PHAX RNA-binding domain mediates auxiliary RNA contracts with small nuclear and mall nucleolar RNA substrates.
Title: Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.
PHAX and CRM1 have roles in transporting U3 snoRNA to nucleoli
Title: PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_115553.1		SNORD3A	BIND	PubMed	Phax interacts with U3 snoRNA
Q9H814	O14980	XPO1	HPRD	PubMed
BioGRID:119734	BioGRID:122516	ASPSCR1	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:116117	GADD45G	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:109143	GRB7	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:114138	MKNK1	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:121014	NSFL1C	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:111196	PDPK1	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:111823	RAD23A	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:112109	RPS6KA1	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:112664	STK3	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119734	BioGRID:114160	TNFSF11	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119734	BioGRID:127913	UBXN2A	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:113252	VAV1	BioGRID	PubMed	Two-hybrid
BioGRID:119734	BioGRID:116303	ZWINT	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
toxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA metabolic process	TAS Traceable Author Statement more info
gene expression	TAS Traceable Author Statement more info
ncRNA metabolic process	TAS Traceable Author Statement more info
protein transport	IEA Inferred from Electronic Annotation more info
snRNA export from nucleus	TAS Traceable Author Statement more info	PubMed
spliceosomal snRNP assembly	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Cajal body	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: phosphorylated adapter RNA export protein

Names: phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor (phosphorylation regulated)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032177.3 → NP_115553.2 phosphorylated adapter RNA export protein

Status: VALIDATED

Source sequence(s)

AC099513, AK023255, BC021161

Consensus CDS

CCDS4138.1

UniProtKB/Swiss-Prot

Q9H814

Related

ENSP00000297540, OTTHUMP00000159192, ENST00000297540, OTTHUMT00000250924

Conserved Domains (1) summary

pfam10258
Location:229 – 315
Blast Score: 338

RNA_GG_bind; PHAX RNA-binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

125936607..125962944

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

121127851..121154385

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC099513.3 (21386..47698)	None
genomic	CH471086.2	EAW48850.1
mRNA	AF086448.1	None
mRNA	AK023255.1	BAB14489.1
mRNA	AK024065.1	BAB14809.1
mRNA	AK225464.1	None
mRNA	AK298497.1	BAG60704.1
mRNA	BC021161.2	AAH21161.1
mRNA	CR457305.1	CAG33586.1
mRNA	N44678.1	None
other-genetic	DQ893213.2	ABM84139.1
other-genetic	DQ896542.2	ABM87541.1