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Tnk2 tyrosine kinase, non-receptor, 2 [ Mus musculus (house mouse) ]

Gene ID: 51789, updated on 15-May-2016
Official Symbol
Tnk2provided by MGI
Official Full Name
tyrosine kinase, non-receptor, 2provided by MGI
Primary source
MGI:MGI:1858308
See related
Ensembl:ENSMUSG00000022791 Vega:OTTMUSG00000026940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ack; Ack1; Pyk1; Ack-1; Cdgip
Orthologs
Location:
16; 16 B3
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (32644099..32683493)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (32644729..32683579)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene SET domain containing 6 pseudogene Neighboring gene transferrin receptor Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC37479

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of clathrin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
coated pit ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
activated CDC42 kinase 1
Names
Cdc42 GTPase-inhibiting protein
P21cdc42Hs kinase
non-receptor protein tyrosine kinase ACK
tyrosine kinase non-receptor protein 2
NP_001103617.1
NP_001276372.1
NP_058068.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110147.1NP_001103617.1  activated CDC42 kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001103617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC052421
    Consensus CDS
    CCDS49828.1
    UniProtKB/Swiss-Prot
    O54967
    UniProtKB/TrEMBL
    A0A0R4J1L0
    Related
    ENSMUSP00000110778, OTTMUSP00000030891, ENSMUST00000115125, OTTMUST00000062602
    Conserved Domains (7) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774841
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14328
    Location:959998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  2. NM_001289443.1NP_001276372.1  activated CDC42 kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks part of the 5' coding region, lacks two in-frame exons in the central coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC161755, BB583500, BC052421
    UniProtKB/Swiss-Prot
    O54967
    Conserved Domains (3) summary
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:284351
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd14328
    Location:469508
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
  3. NM_016788.3NP_058068.2  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_058068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161755, BQ770866, BU702226, DQ666696
    Consensus CDS
    CCDS37313.1
    UniProtKB/Swiss-Prot
    O54967
    UniProtKB/TrEMBL
    G3X9X7
    Related
    ENSMUSP00000110777, OTTMUSP00000030887, ENSMUST00000115124, OTTMUST00000062598
    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789856
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    32644099..32683493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245946.1XP_011244248.1  

    Conserved Domains (7) summary
    pfam09027
    Location:277344
    GTPase_binding; GTPase binding
    pfam11555
    Location:619686
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    smart00221
    Location:1215
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:225274
    SH3_9; Variant SH3 domain
    cd14274
    Location:806849
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:836875
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:1217
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  2. XM_006522335.1XP_006522398.1  

    Conserved Domains (8) summary
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813880
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:150409
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
    cd14274
    Location:10001043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10301069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  3. XM_006522339.1XP_006522402.1  

    Conserved Domains (7) summary
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813880
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:150409
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
    cd14328
    Location:9981037
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  4. XM_006522334.2XP_006522397.1  

    Conserved Domains (8) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821888
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14274
    Location:10051049
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10361075
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  5. XM_006522333.2XP_006522396.1  

    Conserved Domains (8) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821888
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14274
    Location:10081051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10381077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  6. XM_006522337.2XP_006522400.1  

    Conserved Domains (8) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806873
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14274
    Location:9901034
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10211060
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  7. XM_006522332.2XP_006522395.1  

    Conserved Domains (8) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821888
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14274
    Location:10081051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10381077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  8. XM_006522338.2XP_006522401.1  

    Conserved Domains (7) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821888
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  9. XM_006522340.2XP_006522403.1  

    Conserved Domains (7) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806873
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  10. XM_006522336.2XP_006522399.1  

    Conserved Domains (8) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806873
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14274
    Location:9931036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10231062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  11. XM_006522342.2XP_006522405.1  

    Conserved Domains (4) summary
    pfam09027
    Location:39106
    GTPase_binding; GTPase binding
    pfam11555
    Location:381448
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd14274
    Location:568611
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:598637
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
  12. XM_006522345.2XP_006522408.1  

    See identical proteins and their annotated locations for XP_006522408.1

    UniProtKB/TrEMBL
    D3Z3U7
    Related
    ENSMUSP00000110773, OTTMUSP00000030890, ENSMUST00000115120, OTTMUST00000062601
    Conserved Domains (4) summary
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:284351
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd14274
    Location:471514
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:501540
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
  13. XM_006522344.1XP_006522407.1  

    See identical proteins and their annotated locations for XP_006522407.1

    Conserved Domains (4) summary
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:299366
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd14274
    Location:486529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
  14. XM_006522343.1XP_006522406.1  

    See identical proteins and their annotated locations for XP_006522406.1

    Conserved Domains (4) summary
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:299366
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd14274
    Location:486529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    33124376..33163447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)