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RAB8B RAB8B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 51762, updated on 12-May-2016
Official Symbol
RAB8Bprovided by HGNC
Official Full Name
RAB8B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:30273
See related
Ensembl:ENSG00000166128 HPRD:11476; MIM:613532; Vega:OTTHUMG00000132862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
Orthologs
Location:
15q22.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (63189529..63267776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63481728..63559975)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 like Neighboring gene uncharacterized LOC101928972 Neighboring gene aph-1 homolog B, gamma-secretase subunit Neighboring gene uncharacterized LOC105370859 Neighboring gene uncharacterized LOC105370858 Neighboring gene carbonic anhydrase 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
TPR domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization ISS
Inferred from Sequence or Structural Similarity
more info
 
antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of corticotropin secretion IEA
Inferred from Electronic Annotation
more info
 
protein import into peroxisome membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell tip IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ras-related protein Rab-8B
Names
RAB-8b protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016530.2NP_057614.1  ras-related protein Rab-8B

    See identical proteins and their annotated locations for NP_057614.1

    Status: VALIDATED

    Source sequence(s)
    AB038995, AC016207, BG721755
    Consensus CDS
    CCDS10183.1
    UniProtKB/Swiss-Prot
    Q92930
    Related
    ENSP00000312734, OTTHUMP00000163760, ENST00000321437, OTTHUMT00000256336
    Conserved Domains (2) summary
    cd01867
    Location:6172
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
    pfam00071
    Location:10170
    Ras; Ras family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    63189529..63267776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521669.1XP_011519971.1  

    Conserved Domains (1) summary
    cl21455
    Location:682
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006720569.2XP_006720632.1  

    Conserved Domains (1) summary
    cl21455
    Location:191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    63600874..63679075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)