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WBP11 WW domain binding protein 11 [ Homo sapiens (human) ]

Gene ID: 51729, updated on 8-May-2016
Official Symbol
WBP11provided by HGNC
Official Full Name
WW domain binding protein 11provided by HGNC
Primary source
HGNC:HGNC:16461
See related
Ensembl:ENSG00000084463 HPRD:18293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPWBP; SIPP1; WBP-11; PPP1R165
Summary
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12p12.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (14786478..14803467, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14937513..14956420, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene histone cluster 4, H4 Neighboring gene H2A histone family member J Neighboring gene chromosome 12 open reading frame 60 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene ADP-ribosyltransferase 4 (Dombrock blood group)

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
    Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Spliceosome, Prp19/CDC5L complex, conserved biosystem (from KEGG)
    Spliceosome, Prp19/CDC5L complex, conserved biosystemStructural complex; Genetic information processing; Spliceosome
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp779M1063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase type 1 regulator activity IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
WW domain-binding protein 11
Names
Npw38-binding protein NpwBP
SH3 domain-binding protein SNP70
protein phosphatase 1, regulatory subunit 165
splicing factor that interacts with PQBP-1 and PP1
splicing factor, PQBP1 and PP1 interacting

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016312.2NP_057396.1  WW domain-binding protein 11

    See identical proteins and their annotated locations for NP_057396.1

    Status: REVIEWED

    Source sequence(s)
    BC001621
    Consensus CDS
    CCDS8666.1
    UniProtKB/Swiss-Prot
    Q9Y2W2
    UniProtKB/TrEMBL
    A0A024RAW9
    Related
    ENSP00000261167, OTTHUMP00000239327, ENST00000261167, OTTHUMT00000400850
    Conserved Domains (1) summary
    pfam09429
    Location:1294
    Wbp11; WW domain binding protein 11

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    14786478..14803467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    14905505..14922494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)