POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa [Homo sapiens] - Gene

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Summary

Official Symbol: POLR3Kprovided by HGNC
Official Full Name: polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDaprovided by HGNC
Primary source: HGNC:14121
Locus tag: My010
See related: Ensembl:ENSG00000161980; HPRD:16187; MIM:606007; Vega:OTTHUMG00000060722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C11; My010; RPC10; RPC11; hRPC11; RPC12.5; C11-RNP3
Summary: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

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Genomic context

Location :: 16p13.3

Sequence :: Chromosome: 16; NC_000016.9 (96979..103632, complement)

See POLR3K in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Changes in Maf1 expression affect Pol III-dependent transcription in human glioblastoma lines.
Title: Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:119701	BioGRID:107129	POLR3D		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
DNA-directed RNA polymerase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
gene expression	TAS Traceable Author Statement more info
innate immune response	IEA Inferred from Electronic Annotation more info
response to virus	IEA Inferred from Electronic Annotation more info
termination of RNA polymerase III transcription	TAS Traceable Author Statement more info
transcription elongation from RNA polymerase III promoter	TAS Traceable Author Statement more info
transcription from RNA polymerase III promoter	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
DNA-directed RNA polymerase III complex	TAS Traceable Author Statement more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: DNA-directed RNA polymerase III subunit RPC10

Names: DNA-directed RNA polymerase III subunit RPC10; RNA polymerase III subunit C10; RNA polymerase III subunit C11; RNA polymerase III subunit CII; RNA polymerase III 12.5 kDa subunit; RNA polymerase III subunit (hRPC11); DNA-directed RNA polymerase III subunit K; DNA-directed RNA polymerases III 12.5 kDa polypeptide

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016310.3 → NP_057394.2 DNA-directed RNA polymerase III subunit RPC10

Status: REVIEWED

Source sequence(s)

Z69719

Consensus CDS

CCDS10395.1

UniProtKB/Swiss-Prot

Q9Y2Y1

Related

ENSP00000293860, OTTHUMP00000067145, ENST00000293860, OTTHUMT00000134192

Conserved Domains (3) summary

COG1594
Location:1 – 108
Blast Score: 203

RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]

cl02717
Location:4 – 53
Blast Score: 145

RNA_POL_M_15KD; RNA polymerases M/15 Kd subunit

cl02609
Location:69 – 107
Blast Score: 169

TFIIS_C; Transcription factor S-II (TFIIS)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

96979..103632, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

15438..22023, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE006462.1	AAK61210.1
genomic	AF126531.1	AAD31424.1
genomic	CH471112.2	EAW85879.1
genomic	DQ431198.1	ABD95903.1
genomic	Z69719.1	CAI95605.1
mRNA	AF051316.1	AAF18268.1
mRNA	AF060223.1	AAG43123.1
mRNA	BC011932.2	AAH11932.1
other-genetic	DQ896281.2	ABM87280.1
other-genetic	EU176418.1	ABW03869.1