RASD1 RAS, dexamethasone-induced 1 [Homo sapiens] - Gene

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Summary

Official Symbol: RASD1provided by HGNC
Official Full Name: RAS, dexamethasone-induced 1provided by HGNC
Primary source: HGNC:15828
See related: Ensembl:ENSG00000108551; HPRD:08958; MIM:605550; Vega:OTTHUMG00000059292
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AGS1; DEXRAS1; MGC:26290
Summary: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

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Genomic context

Location :: 17p11.2

Sequence :: Chromosome: 17; NC_000017.10 (17397751..17399709, complement)

See RASD1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study showed that Rasd1 and NonO interact at the CRE-site of specific target genes.
Title: Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway.
Rasd1 modulates endogenous renin gene expression by interacting with Ear2.
Title: Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.
Epigenetic inactivation of genes, including RASD1, plays a key role in the development of dexamethasone resistance in multiple myeloma.
Title: Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.
Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1
Title: Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
dex-ras1 mRNA is not induced by glucocorticoid stimulation in HEK293 cells
Title: Dex-ras1 and serum- and glucocorticoid-inducible protein kinase 1: regulation of expression by dexamethasone in HEK293 cells.
A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness
Title: Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene.
yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells demonstrate a direct interaction between AGS1 and the G(beta1) subunit of heterotrimeric G proteins
Title: Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.
does not alter the membrane translocation of protein kinase C delta.
Title: Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling.
Dexras1 plays a critical role in shaping the photic phase response curve (PRC) and the signaling events through which it regulates clock entrainment in transgenic mice.
Title: The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
plays an active role in preventing aberrant cell growth
Title: The Ras-related protein AGS1/RASD1 suppresses cell growth.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y272	P63096	GNAI1	HPRD	PubMed
Q9Y272	P04899	GNAI2	HPRD	PubMed
Q9Y272	P62873	GNB1	HPRD	PubMed
Q9Y272	P29475	NOS1	HPRD	PubMed
Q9Y272	O75052	NOS1AP	HPRD	PubMed
Q9Y272	O15162	PLSCR1	HPRD	PubMed
BioGRID:119662	BioGRID:109032	GNAI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:119662	BioGRID:110905	NOS1	BioGRID	PubMed	Reconstituted Complex
BioGRID:119662	BioGRID:115071	NOS1AP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:119662	BioGRID:111373	PLSCR1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
GTP catabolic process	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
nitric oxide mediated signal transduction	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: dexamethasone-induced Ras-related protein 1

Names: dexamethasone-induced Ras-related protein 1; ras-related protein; activator of G-protein signaling 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028074.1 RefSeqGene

Range

5001..6959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001199989.1 → NP_001186918.1 dexamethasone-induced Ras-related protein 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate splice site in the CDS that results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK294073, BC018041, BC042688

UniProtKB/TrEMBL

B4DFF4

UniProtKB/Swiss-Prot

Q9Y272

Conserved Domains (1) summary

cl09099
Location:25 – 95
Blast Score: 413

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_016084.4 → NP_057168.1 dexamethasone-induced Ras-related protein 1 isoform 1 proprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK312796, BC018041, BC042688

Consensus CDS

CCDS11185.1

UniProtKB/Swiss-Prot

Q9Y272

Related

ENSP00000225688, OTTHUMP00000065541, ENST00000225688, OTTHUMT00000131668

Conserved Domains (1) summary

cd04143
Location:25 – 281
Blast Score: 1114

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

17397751..17399709, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

17150071..17152029, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC073621.21 (2955..4910)	None
genomic	AF222979.1	AAG44256.1
genomic	AF262018.1	AAF72997.1
genomic	CH471196.2	EAW55705.1
mRNA	AF069506.1	AAD34206.1
mRNA	AF153192.1	AAD34621.1
mRNA	AF172846.1	AAF01364.1
mRNA	AF177335.1	AAG17979.1
mRNA	AF498923.1	AAM21071.1
mRNA	AK294073.1	BAG57415.1
mRNA	AK312796.1	BAG35656.1
mRNA	BC018041.1	AAH18041.1
mRNA	BC042688.1	None
other-genetic	AM392981.1	CAL37859.1
other-genetic	AM393158.1	CAL38036.1
other-genetic	AM393716.1	CAL38592.1