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    OTUD6B OTU domain containing 6B [ Homo sapiens ]

    Gene ID: 51633, updated on 11-May-2012
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    Summary

    Official Symbol
    OTUD6Bprovided by HGNC
    Official Full Name
    OTU domain containing 6Bprovided by HGNC
    Primary source
    HGNC:24281
    Locus tag
    CGI-77
    See related
    Ensembl:ENSG00000155100; HPRD:13041; MIM:612021; Vega:OTTHUMG00000150758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUBA5; CGI-77
    Summary
    Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA5 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
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    Genomic context

    Location :
    8q21.3
    Sequence :
    Chromosome: 8; NC_000008.10 (92082424..92099323)
    See OTUD6B in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 55A Neighboring gene uncharacterized LOC100506365 Neighboring gene leucine rich repeat containing 69 Neighboring gene ceruloplasmin (ferroxidase) pseudogene Neighboring gene microRNA 4661

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. Xu Z, et al. PLoS One, 2011 Jan 18. PMID 21267069.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. A data set of human endogenous protein ubiquitination sites. Shi Y, et al. Mol Cell Proteomics, 2011 May. PMID 20972266.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. down-regulation of Otud-6b expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes
      Title: Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:119647 BioGRID:116170 ASCC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119647 BioGRID:124913 MTDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119647 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119647 BioGRID:123917 RPF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119647 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the OTUD6B gene: The OTUD6B gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)
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    General protein information

    Preferred Names
    OTU domain-containing protein 6B
    Names
    OTU domain-containing protein 6B
    DUBA-5
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016023.3 → NP_057107.3  OTU domain-containing protein 6B

      Status: VALIDATED

      Source sequence(s)
      AA748163, AC087439, BC029760, BI712470, DA034027
      Consensus CDS
      CCDS6253.2
      UniProtKB/Swiss-Prot
      Q8N6M0
      Related
      ENSP00000285420, OTTHUMP00000198453, ENST00000285420, OTTHUMT00000319968
      Conserved Domains (1) summary
      cl14910
      Location:183 – 308
      Blast Score: 259
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      92082424..92099323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      87293694..87310590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC087439.6 (22500..39396) None
    genomic CH471060.1 EAW91675.1
      EAW91676.1
    mRNA AA748163.1 None
    mRNA AF151836.1 AAD34073.1
    mRNA AK291646.1 BAF84335.1
    mRNA AK293843.1 BAG57241.1
    mRNA AK310823.1 None
    mRNA AL137441.1 CAB70738.1
    mRNA BC029760.1 AAH29760.1
    mRNA BI712470.1 None
    mRNA BX647772.1 None
    mRNA DA034027.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6M0.1 GenPept UniProtKB/Swiss-Prot:Q8N6M0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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