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    PDK1 pyruvate dehydrogenase kinase, isozyme 1 [ Homo sapiens ]

    Gene ID: 5163, updated on 19-May-2012

    Summary

    Official Symbol
    PDK1provided by HGNC
    Official Full Name
    pyruvate dehydrogenase kinase, isozyme 1provided by HGNC
    Primary source
    HGNC:8809
    See related
    Ensembl:ENSG00000152256; HPRD:03954; MIM:602524; Vega:OTTHUMG00000132285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    2q31.1
    Sequence :
    Chromosome: 2; NC_000002.11 (173420779..173463862)
    See PDK1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 2 Neighboring gene uncharacterized LOC100287375 Neighboring gene integrin, alpha 6 Neighboring gene uncharacterized LOC91149 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 4 Neighboring gene aldehyde dehydrogenase 7 family, member A1 pseudogene 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002601.1 NP_005154.1 AKT1    BIND  PubMed PDK1 interacts with and phosphorylates Akt1. This interaction was modeled on a demonstrated interaction between PDK1 and Akt1, both from unspecified species. 
    Q15118 P10515 DLAT    HPRD  PubMed  
    Q15118 P08559 PDHA1    HPRD  PubMed  
    Q15118 Q15119 PDK2    HPRD  PubMed  
    Q15118 P23443 RPS6KB1    HPRD  PubMed  
    Q15118 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:111189 BioGRID:108081 DLAT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111189 BioGRID:108757 MTOR    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:111189 BioGRID:111190 PDK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111189 BioGRID:111571 PKN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111189 BioGRID:111572 PKN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111189 BioGRID:111836 RALGDS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111189 BioGRID:112112 RPS6KB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111189 BioGRID:121582 RPTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111189 BioGRID:112344 SGK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111189 BioGRID:108822 XRCC6    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    • Homologs of the PDK1 gene: The PDK1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
      EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pyruvate metabolism, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
    • Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
    • Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem (from REACTOME)
      Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystemThe mitochondrial pyruvate dehydrogenase (PDH) complex catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. PDH inactivati...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCA Cycle, organism-specific biosystem (from WikiPathways)
      TCA Cycle, organism-specific biosystemThe [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-cata...
    • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
      The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    two-component sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-histidine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    pyruvate metabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pyruvate dehydrogenase kinase, isozyme 1
    Names
    pyruvate dehydrogenase kinase, isozyme 1
    pyruvate dehydrogenase kinase, isoenzyme 1
    mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1
    NP_002601.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002610.3NP_002601.1  pyruvate dehydrogenase kinase, isozyme 1

      Status: REVIEWED

      Source sequence(s)
      AC018712, AU118504, L42450
      Consensus CDS
      CCDS2250.1
      UniProtKB/Swiss-Prot
      Q15118
      Related
      ENSP00000282077, OTTHUMP00000163127, ENST00000282077, OTTHUMT00000255380
      Conserved Domains (2) summary
      cd00075
      Location:273389
      Blast Score: 172
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      pfam10436
      Location:55221
      Blast Score: 555
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      173420779..173463862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      165298977..165342087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC018712.5 (153477..156500) None
    genomic AC093818.3 AAY14915.1
    genomic CH471058.2 EAX11173.1
      EAX11174.1
    mRNA AK056110.1 None
    mRNA AK294194.1 BAH11693.1
    mRNA AK302321.1 BAH13672.1
    mRNA AK304388.1 BAH14173.1
    mRNA AK312700.1 BAG35578.1
    mRNA AU118504.2 None
    mRNA BC039158.1 AAH39158.1
    mRNA DQ234350.1 ABB29979.1
    mRNA L42450.1 AAC42009.1
    other-genetic DQ891300.2 ABM82226.1
    other-genetic DQ893348.2 ABM84274.1
    other-genetic DQ894484.2 ABM85410.1
    other-genetic DQ896668.2 ABM87667.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15118.1 GenPept UniProtKB/Swiss-Prot:Q15118
    Q308M4 GenPept UniProtKB/TrEMBL:Q308M4
    Q53R49 GenPept UniProtKB/TrEMBL:Q53R49

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